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Volume 26, Number 11—November 2020

Modeling Treatment Strategies to Inform Yaws Eradication

Alex HolmesComments to Author , Michael J. Tildesley, Anthony W. Solomon, David C.W. Mabey, Oliver Sokana, Michael Marks, and Louise Dyson
Author affiliations: Mathematics Institute, University of Warwick, Coventry, UK (A. Holmes, M.J. Tildesley, L. Dyson); University of Warwick School of Life Sciences, Coventry (M.J. Tildesley, L. Dyson); Hospital for Tropical Diseases, London, UK (A.W. Solomon, D.C.W. Mabey, M. Marks); London School of Hygiene and Tropical Medicine, London (A.W. Solomon, D.C.W. Mabey, M. Marks); Ministry of Health and Medical Services, Honiara, Solomon Islands (O. Sokana)

Main Article

Table 1

Permitted state transitions and state transition rates for steady state household model of yaws transmission*

Description State transition Rate
Infection, external (ε) and within-household (β) (S,I,A) ® (S-1,I+1,A)
Treatment/birth-death (S,I,A) ® (S+1,I-1,A) δ
Remission (S,I,A) ® (S,I-1,A+1) λ
Recurrence (S,I,A) ® (S,I+1,A-1) ρ
Treatment/birth-death (S,I,A) ® (S+1,I,A-1) δ

*Methods described in Appendix . A, asymptomatically infected (but not infectious); I, infected and infectious; S, susceptible.

Main Article

Page created: August 18, 2020
Page updated: October 17, 2020
Page reviewed: October 17, 2020
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