Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 26, Number 11—November 2020

Modeling Treatment Strategies to Inform Yaws Eradication

Alex HolmesComments to Author , Michael J. Tildesley, Anthony W. Solomon, David C.W. Mabey, Oliver Sokana, Michael Marks, and Louise Dyson
Author affiliations: Mathematics Institute, University of Warwick, Coventry, UK (A. Holmes, M.J. Tildesley, L. Dyson); University of Warwick School of Life Sciences, Coventry (M.J. Tildesley, L. Dyson); Hospital for Tropical Diseases, London, UK (A.W. Solomon, D.C.W. Mabey, M. Marks); London School of Hygiene and Tropical Medicine, London (A.W. Solomon, D.C.W. Mabey, M. Marks); Ministry of Health and Medical Services, Honiara, Solomon Islands (O. Sokana)

Main Article

Table 2

Parameter values for household structured yaws transmission model, based on data collected from the Solomon Islands*

Parameter Value Source
β 0.0516 (13)
δ 0.0513 (13)
λ 0.185 (14,15)
ρ 0.0165 (13)
ε† 0.004 (13)
α‡ 0.1669 Appendix

*Given parameter value is the maximum posterior value of the distribution from which each parameter is drawn, with the exception of λ which is consistent with expert opinion. Methods described in Appendix.
†Steady state external force of infection.
‡Between-household rate of infection corresponding to a steady state external force of infection ε.

Main Article

  1. Mitjà  O, Asiedu  K, Mabey  D. Yaws. Lancet. 2013;381:76373. DOIPubMedGoogle Scholar
  2. Antal  GM, Causse  G. The control of endemic treponematoses. Rev Infect Dis. 1985;7(Suppl 2):S2206. DOIPubMedGoogle Scholar
  3. Mitjà  O, Houinei  W, Moses  P, Kapa  A, Paru  R, Hays  R, et al. Mass treatment with single-dose azithromycin for yaws. N Engl J Med. 2015;372:70310. DOIPubMedGoogle Scholar
  4. Mitjà  O, Hays  R, Ipai  A, Penias  M, Paru  R, Fagaho  D, et al. Single-dose azithromycin versus benzathine benzylpenicillin for treatment of yaws in children in Papua New Guinea: an open-label, non-inferiority, randomised trial. Lancet. 2012;379:3427. DOIPubMedGoogle Scholar
  5. World Health Organization. Accelerating work to overcome the global impact of neglected tropical diseases: a roadmap for implementation—executive summary. 2012 [cited 2020 Apr 22].
  6. World Health Organization. NTD roadmap landscape 2021–2030. 2019 [cited 2020 Apr 22].
  7. World Health Organization. Eradication of yaws—the Morges strategy. Wkly Epidemiol Rec. 2012;87:18994.PubMedGoogle Scholar
  8. World Health Organization. Eradication strategy—the new eradication initiative [cited 2020 Apr 22].
  9. World Health Organization. Eradication of yaws: a guide for programme managers. 2018 [cited 2020 Apr 22].
  10. Marks  M, Mitjà  O, Solomon  AW, Asiedu  KB, Mabey  DC. Yaws. Br Med Bull. 2015;113:91100. DOIPubMedGoogle Scholar
  11. World Health Organization. Handbook of endemic treponematoses: yaws, endemic syphilis, and pinta. 1984 [cited 2020 Apr 22]. https://w]
  12. Marks  M, Solomon  AW, Mabey  DC. Endemic treponemal diseases. Trans R Soc Trop Med Hyg. 2014;108:6017. DOIPubMedGoogle Scholar
  13. Marks  M, Vahi  V, Sokana  O, Puiahi  E, Pavluck  A, Zhang  Z, et al. Mapping the epidemiology of yaws in the Solomon Islands: a cluster randomized survey. Am J Trop Med Hyg. 2015;92:12933. DOIPubMedGoogle Scholar
  14. Dyson  L, Marks  M, Crook  OM, Sokana  O, Solomon  AW, Bishop  A, et al. Targeted treatment of yaws with household contact tracing: how much do we miss? Am J Epidemiol. 2018;187:83744. DOIPubMedGoogle Scholar
  15. Daniel  T. Gillespie. Exact stochastic simulation of coupled chemical reactions. J Phys Chem. 1977;81:234061. DOIGoogle Scholar
  16. Marks  M, Mitjà  O, Fitzpatrick  C, Asiedu  K, Solomon  AW, Mabey  DCW, et al. Mathematical modeling of programmatic requirements for yaws eradication. Emerg Infect Dis. 2017;23:228. DOIPubMedGoogle Scholar
  17. Dyson  L, Stolk  WA, Farrell  SH, Hollingsworth  TD. Measuring and modelling the effects of systematic non-adherence to mass drug administration. Epidemics. 2017;18:5666. DOIPubMedGoogle Scholar
  18. Fitzpatrick  C, Asiedu  K, Jannin  J. Where the road ends, yaws begins? The cost-effectiveness of eradication versus more roads. PLoS Negl Trop Dis. 2014;8:e3165. DOIPubMedGoogle Scholar
  19. Mitjà  O, Godornes  C, Houinei  W, Kapa  A, Paru  R, Abel  H, et al. Re-emergence of yaws after single mass azithromycin treatment followed by targeted treatment: a longitudinal study. Lancet. 2018;391:1599607. DOIPubMedGoogle Scholar
  20. Mitjà  O, Marks  M, Bertran  L, Kollie  K, Argaw  D, Fahal  AH, et al. Integrated control and management of neglected tropical skin diseases. PLoS Negl Trop Dis. 2017;11:e0005136. DOIPubMedGoogle Scholar
  21. World Health Organization. Recognizing neglected tropical diseases through changes on the skin: a training guide for front-line health workers. 2018 [cited 2020 Apr 22].
  22. Amza  A, Kadri  B, Nassirou  B, Cotter  SY, Stoller  NE, Zhou  Z, et al. A cluster-randomized trial to assess the efficacy of targeting trachoma treatment to children. Clin Infect Dis. 2017;64:74350.PubMedGoogle Scholar
  23. Šmajs  D, Paštěková  L, Grillová  L. Macrolide resistance in the syphilis spirochete, Treponema pallidum ssp. pallidum: can we also expect macrolide-resistant yaws strains? Am J Trop Med Hyg. 2015;93:67883. DOIPubMedGoogle Scholar

Main Article

Page created: August 18, 2020
Page updated: October 17, 2020
Page reviewed: October 17, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.