Endotheliopathy and Platelet Dysfunction as Hallmarks of Fatal Lassa Fever
Lucy E. Horton1
, Robert W. Cross1
, Jessica N. Hartnett, Emily J. Engel, Saori Sakabe, Augustine Goba, Mambu Momoh, John Demby Sandi, Thomas W. Geisbert, Robert F. Garry, John S. Schieffelin, Donald S. Grant, and Brian M. Sullivan
Author affiliations: The Scripps Research Institute, La Jolla, California, USA (L.E. Horton, S. Sakabe, B.M. Sullivan); University of Texas Medical Brach, Galveston, Texas, USA (R.W. Cross, T.W. Geisbert); Tulane University School of Medicine, New Orleans, Louisiana, USA (J.N. Hartnett, E.J. Engel, R.F. Garry, J.S. Schieffelin); Kenema Government Hospital, Kenema, Sierra Leone (A. Goba, M. Momoh, J.D. Sandi, D.S. Grant); Ministry of Health and Sanitation, Freetown, Sierra Leone (A. Goba, M. Momoh, J.D. Sandi); Eastern Polytechnic Institute, Kenema (M. Momoh, D.S. Grant); Njala University, Moyamba, Sierra Leone (J.D. Sandi); University of Sierra Leone, Freetown (D.S. Grant)
Figure 4. Hepatocyte growth factor plasma levels in patients with acute LF and liver function tests in acute LF cases, Sierra Leone, 2015–2018. A) HGF was positively correlated with total bilirubin (n = 23), alkaline phosphatase (n = 26), AST (n = 26), and ALT (n = 27). B) HGF levels in acute LF patients were statistically significantly higher (***p = 0.0005) in patients who died (n = 14) than those who survived (n = 7), and a statistically significant positive correlation between HGF and LASV antigen was observed in LF patients (n = 22). Dashed lines and gray shading indicate limits of detection. ALT, alanine aminotransferase; AST, aspartate aminotransferase; D, died; HGF, hepatocyte growth factor; LF, Lassa fever; LASV-Ag, Lassa fever virus antigen; S, survived.
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