Volume 26, Number 11—November 2020
CME ACTIVITY - Research
Phage-Mediated Immune Evasion and Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus in Humans
Table 1
Distribution of IEC-harboring ΦSa3int prophages among livestock-associated methicillin-resistant Staphylococcus aureus CC398 isolates from North Denmark Region, Denmark*
Variant | Phylogenetic cluster† | IEC type | Integration site‡ | tarP | Isolate origin | Household ID | Farm ID |
---|---|---|---|---|---|---|---|
I | A | B | 0723–0724 | – | 1 pig farm employee and 4 household members | H02 | F01 |
II | B | E | 2238 | – | 1 pig farm employee and 1 household member | H30 | F01 |
III | C | B | 2059 (hlb) | – | 1 pig farm employee and 3 household members | H63 | F04 |
IV | D | B | 2591 (cidA) | – | 1 pig farm employee | H51 | F07 |
V | E | F | 2059 (hlb) | + | 1 pig veterinarian | H46 | None |
VI | E | F | 2644 | + | 1 mink farm employee and 3 household members | H49 | F21 |
E | F | 2644 | + | Pig | NA | A | |
E | F | 2644 | + | Pig | NA | B | |
E | F | 2644 | + | Pig | NA | C |
*Allocation of ΦSa3int prophages into variants (ΦSa3int-I to ΦSa3int-VI) was based on their phylogenetic relationship, IEC type, and chromosomal integration site. CC, clonal complex; ID, identification; IEC, immune evasion cluster; NA, not applicable; –, negative, +, positive. †Phylogenetic clusters are illustrated in Figure 1. ‡Numbers refer to annotated genes in reference strain S0385 (GenBank accession no. NC_017333).
1These senior authors contributed equally to this article.