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Volume 26, Number 11—November 2020
Research

Three Patients with COVID-19 and Pulmonary Tuberculosis, Wuhan, China, January–February 2020

Zhi Yao1, Junbo Chen1, Qianli Wang1, Weiyong Liu1, Qi Zhang1, Jing Nan, Hai Huang, Yuying Wu, Lan Li, Lu Liang, Lei You, Yingle Liu2Comments to Author , and Hongjie Yu2Comments to Author 
Author affiliations: Wuhan Pulmonary Hospital, Wuhan, China (Z. Yao, J. Nan, H. Huang, Y. Wu, L. Li); School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China (J. Chen, Q. Wang, L. You, H. Yu); Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan (W. Liu); Wuhan University, State Key Laboratory of Virology, Wuhan (Q. Zhang, Y. Liu); Sichuan University, Chengdu, China (L. Liang)

Main Article

Table

Summary of clinical characteristics and clinical laboratory results for 3 patients with coronavirus disease and tuberculosis, Wuhan, China, January–February 2020*

Characteristics Patient 1 Patient 2 Patient 3
Age, y 50 44 57
Smoker + + –
Underlying medical conditions†
 –
 +
 +
Signs and symptoms‡
Fever + + +
Cough + + +
Fatigue + + +
Wheeze + + +
Chills – + –
Weight loss + + +
Night sweats NA + –
Vomiting – – –
Diarrhea – – –
Tachycardia – + –
Tachypnoea
 +
 –
 +
Laboratory findings§
Leukocyte count, × 109 cells/L (reference range 3.5–9.5 × 109 cells/L) 10.4 (↑) 6.86 8.86
Neutrophil count, ×109 cells/L (reference range 1.8–6.3 × 109 cells/L) 8.74 (↑) 4.35 7.74 (↑)
Lymphocyte count ×109 cells/L (reference range 1.1–3.2 × 109 cells/L) 0.73 (↓) 1.75 0.74 (↓)
T-cell count, cells/μL (reference range 690–2,540 cells/μL) NA 1,092.92 282.12 (↓)
CD4+ T-cell percentage (reference range 40%–57%) NA 25.3 (↓) 25.91 (↓)
CD4+ T-cell count, cells/μL (reference range 410–1,590 cells/μL) NA 415.51 138.91 (↓)
CD8+ T-cell percentage (reference range 8%–37%) NA 36.67 19.37
CD8+ T-cell count, cells/μL (reference range 190–1,140 cells/μL) NA 602.14 103.8 (↓)
CD4+ to CD8+ T-cell count ratio (reference range 0.71–2.78) NA 0.69 (↓) 1.34
Hemoglobin, g/L (reference range 130–175 g/L) 83 (↓) 127 (↓) 134
Platelet count, ×109/L (reference range 125–350 109/L) 430 (↑) 280 218
Activated partial thromboplastin time, s (reference range 27–45 s) 45.5 (↑) 36.4 30.8
Prothrombin time, s (reference range 11–16 s) 18.4 (↑) 13.3 16.29
International normalized ratio (reference range 0.8–1.3) 1.44 (↑) 1.03 1
Fibrinogen, g/dL (reference range 2–4 g/dL) 8.01 (↑) 4.5 (↑) 5.07 (↑)
D–dimer, μg/L (reference range 0–0.5 μg/L) 1.58 (↑) 3.7 (↑) NA
Alanine aminotransferase, U/L (reference range 9–50 U/L) 9 12 52 (↑)
Aspartate aminotransferase, U/L (reference range 15–40 U/L) 3 (↓) 11 (↓) 45 (↑)
Albumin, g/L (reference range 35–55 g/L) 29.9 (↓) 36.7 35.6
Bilirubin, μmol/L (reference range 0–21 μmol/L) 2.56 5 4.15
Creatinine, μmol/L (reference range 44–115 μmol/L) 38 (↓) NA 64
Lactate dehydrogenase, U/L (reference range 106–245 U/L) 170 NA 367 (↑)
Creatine kinase, U/L (reference range 24.0–194.0 U/L) 31 24.7 45.1
Creatine kinase isoenzyme, U/L (reference range 0–24 U/L) 9 12.6 22.6
Bicarbonate, mmol/L (reference range 22–27 mmol/L) 21.4 29.9 (↑) 29.8 (↑)
C-reactive protein, mg/L (reference range 0.0–5.0 mg/L) 293.8 (↑) 3.99 44.4 (↑)
Procalcitonin, ng/mL (reference range 0.00–0.25 ng/mL) 0.14 0.04 0.04
Erythrocyte sedimentation rate, mm/h; (reference range 0–15 mm/h)
 123 (↑)
 81 (↑)
 53 (↑)
Chest CT findings
Ground-glass opacities + + +
Pleural effusion
 +
 +
 –
Treatment
Antibiotics + + +
Anti-TB therapy + + –
Lopinavir/ritonavir – + +
Umifenovir hydrochloride – + –
Interferon–α – + +
Corticosteroid + – +
Immunoglobulin – – +
Oxygen support + – +
Clinical course
Duration of hospitalization, d 22 26 27
Time from illness onset to discharge or death, d
 35
 47
 46
Clinical severity Severe Moderate Severe
Outcome Died Survived Survived

*All patients were male. CT, computed tomography; NA, not available; TB, tuberculosis; ↑, values higher than reference range; ↓, values lower than reference range.; +, positive; –, negative.
†Patients 2 and 3 had type 2 diabetes mellitus.
‡At admission to the original hospital.
§Test results after transfer to the Wuhan Pulmonary Hospital.

Main Article

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: July 15, 2020
Page updated: October 19, 2020
Page reviewed: October 19, 2020
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