William T. Hu
, J. Christina Howell, Tugba Ozturk, Karima Benameur, Leda C. Bassit, Richard Ramonell, Kevin S. Cashman, Shama Pirmohammed, John D. Roback, Vincent C. Marconi, Irene Yang, Valerie V. Mac, Daniel Smith, Ignacio Sanz, Whitney Wharton, F. Eun-Hyung Lee, and Raymond F. Schinazi
Figure 2. Severe acute respiratory syndrome coronavirus 2 virus neutralization measures according to anti-S1-RBD IgG and anti-S1 IgM levels, Atlanta, Georgia, USA, 2020. Open circles represent negative plaque-reduction neutralization test (PRNT) result, and solid circles represent positive PRNT result (sizes of filled circles are proportional to maximal dilution with positive PRNT result). Dotted lines indicate threshold values. A) Among participants with coronavirus disease (COVID-19) (mild disease and hospitalized), pre-2020 controls with elevated antibody levels, and pre-2020 controls with normal antibody levels, positive PRNT results were most associated with simultaneously elevated IgM and IgG levels (Appendix). B) Analysis of a group of 116 persons who reported recovery from self-limited illness 7–60 days prior showed a similar trend. ND, not done; RBD, receptor-binding domain; S1, spike protein subunit 1.