Volume 26, Number 2—February 2020
CME ACTIVITY - Research
Illness Severity in Hospitalized Influenza Patients by Virus Type and Subtype, Spain, 2010–2017
Concepción Delgado-Sanz
, Clara Mazagatos-Ateca, Jesús Oliva, Alin Gherasim, and Amparo Larrauri
, Clara Mazagatos-Ateca, Jesús Oliva, Alin Gherasim, and Amparo Larrauri
Table 2
Clinical complications and final outcomes of patients hospitalized for laboratory-confirmed severe influenza, by influenza virus type or subtype, Spain, influenza seasons 2010–11 to 2016–17*
| Complication and outcome |
Influenza virus type or subtype |
|||||||
| pH1N1 |
A(H3N2) |
B |
||||||
| No. (%) |
No. (%) |
Crude OR† (95% CI) |
No. (%) |
Crude OR‡ (95% CI) |
||||
| Total no. patients |
4,568 (100) |
3,091 (100) |
NA |
1,326 (100) |
NA |
|||
| Pneumonia | 3,529 (78) | 2,154 (71) | 0.68 (0.61–0.76) | 951 (74) | 0.77 (0.67–0.89) | |||
| Missing data |
71 (2) |
69 (2) |
NA |
36 (3) |
NA |
|||
| Co-infection | 903 (26) | 680 (31) | 1.23 (1.09–1.38) | 320 (34) | 1.43 (1.22–1.67) | |||
| Missing data |
1,153 (25) |
873 (28) |
NA |
383 (29) |
NA |
|||
| ARDS | 1,220 (29) | 571 (22) | 0.69 (0.61–0.77) | 271 (23) | 0.73 (0.63–0.85) | |||
| Missing data |
405 (9) |
528 (17) |
NA |
160 (12) |
NA |
|||
| MODS | 405 (10) | 236 (9) | 0.94 (0.79–1.11) | 107 (9) | 0.94 (0.75–1.17) | |||
| Missing data |
467 (10) |
559 (18) |
NA |
177 (13) |
NA |
|||
| ICU admission | 1,787 (41) | 820 (28) | 0.55 (0.50–0.61) | 389 (31) | 0.64 (0.56–0.73) | |||
| Missing data |
245 (5) |
146 (5) |
NA |
77 (6) |
NA |
|||
| Case-fatality rate | ||||||||
| Deaths in hospitalized patients | 585 (14) | 493 (16) | 1.25 (1.10–1.43) | 130 (11) | 0.76 (0.62–0.93) | |||
| Deaths in ICU patients | 405 (24) | 180 (23) | 0.90 (0.74–1.11) | 68 (19) | 0.73 (0.55–0.97) | |||
| Missing data | 254 (6) | 89 (3) | NA | 109 (8) | NA | |||
*ARDS, acute respiratory distress syndrome; ICU, intensive care unit; MODS, multiple organ dysfunction syndrome; NA, not applicable; OR, odds ratio.
†OR of influenza A(H3N2) compared with pH1N1 (reference).
‡OR of influenza B compared with pH1N1 (reference).
Page created: January 16, 2020
Page updated: January 16, 2020
Page reviewed: January 16, 2020
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