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Volume 26, Number 2—February 2020

Neutralizing Antibodies against Enteroviruses in Patients with Hand, Foot and Mouth Disease

Lam Anh NguyetComments to Author , Tran Tan Thanh, Le Nguyen Thanh Nhan, Nguyen Thi Thu Hong, Le Nguyen Truc Nhu, Hoang Minh Tu Van, Nguyen Thi Han Ny, Nguyen To Anh, Do Duong Kim Han, Ha Manh Tuan, Vu Quang Huy, Ho Lu Viet, Hoang Quoc Cuong, Nguyen Thi Thanh Thao, Do Chau Viet, Truong Huu Khanh, Louise Thwaites, Hannah Clapham, Nguyen Thanh Hung, Nguyen Van Vinh Chau, Guy Thwaites, Do Quang Ha, H. Rogier van Doorn, and Le Van TanComments to Author 
Author affiliations: Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam (L.A. Nguyet, T.T. Thanh, N.T.T. Hong, L.N.T. Nhu, H.M.T. Van, N.T.H. Ny, N.T. Anh, D.D.K. Han, L. Thwaites, H. Clapham, G. Thwaites, D.Q. Ha, H.R. van Doorn, L.V. Tan); Children’s Hospital 1, Ho Chi Minh City (L.N.T. Nhan, T.H. Khanh, N.T. Hung); Children’s Hospital 2, Ho Chi Minh City (H.M. Tuan, H.L. Viet, D.C. Viet); University of Medicine and Pharmacy, Ho Chi Minh City (H.M. Tuan, V.Q. Huy); Pasteur Institute, Ho Chi Minh City (H.Q. Cuong, N.T.T. Thao); University of Oxford, Oxford, UK (L. Thwaites, H. Clapham, G. Thwaites, H.R. van Doorn); Hospital for Tropical Diseases, Ho Chi Minh City (N.V.V. Chau)

Main Article

Table 3

Geometric mean titers of neutralizing antibodies against enteroviruses in study of patients with hand, foot and mouth disease, Vietnam*

Virus Samples Geometric mean titer (95% CI) of neutralizing antibodies
Enrollment 4.9 (3.6–6.7) 13.3 (6.8–26.1) 6.9 (4.3–11.3) 5.0 (3.6–7.0)
Follow-up 151.4 (113.0–202.8) 13.0 (6.4–26.2) 10.8 (5.6–20.8) 6.0 (3.8–9.7)
p value
Enrollment 6.2 (3.9–9.7) 10.1 (5.7–17.7) 5.3 (3.8–7.2) 5.9 (3.8–9.7)
Follow-up 8.7 (4.8–16.1) 245.5 (181.1–332.7) 6.3 (4.0–10.1) 7.6 (4.3–13.8)
p value
Enrollment 9.0 (5.0–16.0) 13.6 (6.9–26.7) 10.5 (5.7–18.6) 7.4 (4.3–12.9)
Follow-up 10.3 (5.7–18.7) 14.6 (7.5–28.5) 141.2 (104.547–191.0) 9.8 (5.1–18.7)
p value
EV-A71 Enrollment 6.6 (4.2–10.4) 23.2 (11.5–46.7) 7.6 (4.4–13.0) 37.7 (17.9–79.4)
Follow-up 9.4 (5.3–16.7) 18.8 (10.0–35.4) 10.1 (5.4–18.7) 295.1 (260.6–334.2)
p value 0.073 0.31 0.25 <0.001

*p values reflect the results of statistical analysis comparing the geometric mean titers between the 2 time points (enrollment and follow-up) of the corresponding enterovirus serotypes. CV, coxsackievirus; EV, enterovirus; HFMD, hand, foot and mouth disease.

Main Article

Page created: January 17, 2020
Page updated: January 17, 2020
Page reviewed: January 17, 2020
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