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Volume 26, Number 3—March 2020
Research

Randomized Trial of 2 Schedules of Meningococcal B Vaccine in Adolescents and Young Adults, Canada1

Joanne M. LangleyComments to Author , Soren Gantt, Caroline Quach, Julie A. Bettinger, Scott A. Halperin, Jill Mutch, Shelly A. McNeil, Brian J. Ward, Donna MacKinnon-Cameron, Lingyun Ye, Kim Marty, David Scheifele, Erin Brown, Joenel Alcantara, and The Canadian Immunization Research Network
Author affiliations: Canadian Center for Vaccinology, Dalhousie University, IWK Health Centre, and Nova Scotia Health Authority, Halifax, Nova Scotia, Canada (J.M. Langley, S.A. Halperin, J. Mutch, S.A. McNeil, D. MacKinnon-Cameron, L. Ye); Vaccine Evaluation Center, University of British Columbia, Vancouver, British Columbia, Canada (S. Gantt, J.A. Bettinger, K. Marty, D. Scheifele); University of Montreal, Montreal, Quebec, Canada (C. Quach); Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada (C. Quach, B.J. Ward); University of Calgary, Calgary, Alberta, Canada (E. Brown, J. Alcantara)

Main Article

Table 2

Percentage of participants with hSBA titers >1:4 by strain in a trial of MenB-4C vaccine from day 0 to day 180, Canada*

Meningococcal strain
 Participants with hSBA, % (95% CI)
Day 0
 Day 21
 Day 42
 Day 81
 Day 180
5/99
Accelerated 67.2 (53.7–79.0) 100 (93.8–100) 100 (93.7–100) 100 (93.7–100) 100 (93.7–100)
Longer interval
 89.7 (78.8–96.1)
 98.3 (90.8–100)
 98.3 (90.8–100)
 100 (93.8–100)
 100 (93.7–100)
H44/76
Accelerated 20.7 (11.2–33.4) 98.3 (90.8–100) 98.2 (90.6–100) 98.2 (90.6–100) 96.5 (87.9–99.6)
Longer interval
 43.1 (30.2–56.8)
 98.3 (90.8–100)
 96.6 (88.1–99.6)
 100 (93.8–100)
 100 (93.7–100)
NZ98/254
Accelerated 51.7 (38.2–65.0) 98.3 (90.8–100) 100 (93.7–100) 100 (93.7–100) 98.2 (90.6–100)
Longer interval 65.5 (51.9–77.5) 100 (93.8–100) 100 (93.8–100) 100 (93.8–100) 98.2 (90.6–100)

*The accelerated schedule was MenB-4C vaccine at 0 and 21 days. The longer interval schedule was MenB-4C vaccine at 0 and 60 days. 5/99, Neisserial adhesin A surface proteins; H44/76, factor H binding protein; hSBA, human serum bactericidal antibody; MenB, Neisseria meningitidis serotype B; MenB-4C, 4-component protein-based menB; NZ98/254, New Zealand outer membrane vesicle.

Main Article

1Preliminary results from this study were presented at IDWeek, October 26–30, 2016, New Orleans, LA, USA; and at the Meningitis Research Foundation Conference, November 14–15, 2017, London, England, UK.

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Page updated: February 19, 2020
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