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Volume 26, Number 3—March 2020
Research

Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015

Matthias MerkerComments to Author , Elena Nikolaevskaya, Thomas A. Kohl, Barbara Molina-Moya, Olha Pavlovska, Patrik Brännberg, Andrii Dudnyk, Valentyna Stokich, Ivan Barilar, Iryna Marynova, Tetiana Filipova, Cristina Prat, Anders Sjöstedt, Jose Dominguez, Olena RzhepishevskaComments to Author , and Stefan Niemann
Author affiliations: Research Center Borstel, Borstel, Germany (M. Merker, T.A. Kohl, I. Barilar, S. Niemann); Odessa Regional TB Hospital, Odessa, Ukraine (E. Nikolaevskaya, O. Pavlovska, V. Stokich); Institut d'Investigació Germans Trias i Pujol, Badalona, Spain (B. Molina-Moya, C. Prat, J. Dominguez); Centro de Investigación Biomédica en Red (CIBERES), Badalona (B. Molina-Moya, C. Prat, J. Dominguez); Universitat Autònoma de Barcelona, Barcelona, Spain (B. Molina-Moya, C. Prat, J. Dominguez); Umeå University, Umea, Sweden (P. Brännberg, A. Sjöstedt, O. Rzhepishevska); National Pirogov Memorial Medical University, Vinnytsia, Ukraine (A. Dudnyk); Odessa I.I. Mechnikov National University, Odessa (I. Marynova, T. Filipova); German Center for Infection Research, Hamburg-Lübeck-Borstel-Riems, Germany (S. Niemann)

Main Article

Table 1

Factors associated with MDR/XDR TB in southern Ukraine, analyzed by logistic regression*

Factor No. (%) cases MDR/XDR TB, n = 74 Univariate analysis
 Multivariate analysis†
OR (95% CI) p value Adjusted OR (95% CI) Adjusted p value
Age, y
<30 15 (20.3) 3.0 (1.0–8.3) 0.04 0.9 (0.2–4.0) 0.87
30–39 23 (31.1) 1.5 (0.6–3.5) 0.39 0.9 (0.3–3.1) 0.95
40–49 24 (32.4) 1.6 (0.7–3.9) 0.27 0.8 (0.1–5.2) 0.78
>50
 12 (16.2)
 Referent
Case
Previous treatment 33 (44.6) 3.3 (1.7–6.5) <0.001 3.5 (1.0–12.8) 0.04
New case
 41 (55.4)
 Referent
Sex
M 50 (67.6) 0.9 (0.5–1.8) 0.85 3.0 (0.6–15.5) 0.12
F
 24 (32.4)
 Referent
HIV status
Positive 24 (32.4) 1.5 (0.8–2.9) 0.23 0.8 (0.1–6.2) 0.81
Negative
 50 (67.6)
 Referent
Residence
Unknown 5 (6.8) 0.5 (0.1–1.5) 0.21 0.7 (NA)† 0.68
City 27 (36.5) 2.1 (1.1–4.2) 0.03 6.0 (NA)† 0.005
Village
 42 (56.8)
 Referent
Outbreak
Yes 51 (68.9) 112 (25.4–493.4) ≤0.001 7.4 (1.8–29.9) ≤0.001
No
 23 (31.1)
 Referent
MTBC genotype†
Beijing 61 (82.4) 3.5 (1.3–9.5) 0.01
H37Rv-like 0 (0) NA 0.99
Ghana 2 (2.7) 0.5 (0.1–3.4) 0.51
Haarlem 0(0) NA 0.99
Ural 3 (4.1) 0.6 (0.1–3.0) 0.54
LAM 8 (10.8) Referent

*Bold text indicates significance (p≤0.05). MDR, multidrug-resistant; MTBC, Mycobacterium tuberculosis complex; NA, not available; OR, odds ratio; TB, tuberculosis; XDR, extensively drug resistant.
†MTBC genotype contains categories with 0 events; thus, in the multivariate analysis, OR could not be calculated and OR 95% CI reached infinity.

Main Article

Page created: February 20, 2020
Page updated: February 20, 2020
Page reviewed: February 20, 2020
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