TY - JOUR AU - Guan, Qingtian AU - Almutairi, Talal AU - Alhalouli, Tahani AU - Pain, Arnab AU - Alasmari, Faisal T1 - Metagenomics of Imported Multidrug-Resistant Mycobacterium leprae, Saudi Arabia, 2017 T2 - Emerging Infectious Disease journal PY - 2020 VL - 26 IS - 3 SP - 615 SN - 1080-6059 AB - Using shotgun metagenomics, we identified an imported case of multidrug-resistant Mycobacterium leprae in a Filipino resident of Saudi Arabia in 2017. We determined the phylogenomic lineage (3K1) and identified mutations in rpoB and rrs corresponding to the multidrug-resistance phenotype clinically observed. Metagenomics sequencing can be used to identify multidrug-resistant M. leprae. KW - Mycobacterium leprae KW - metagenomics KW - drug resistance KW - imported infectious diseases KW - tuberculosis and other mycobacteria KW - rpoB KW - rrs KW - Philippines KW - Saudi Arabia KW - single-nucleotide polymorphisms KW - indels KW - antimicrobial resistance KW - leprosy KW - bacteria KW - biopsy KW - 3K1 DO - 10.3201/eid2603.190661 UR - https://wwwnc.cdc.gov/eid/article/26/3/19-0661_article ER - End of Reference