Table 2

Genomic and Phenotypic Variability in Neisseria gonorrhoeae Antimicrobial Susceptibility, England

Katy Town

, Simon Harris, Leonor Sánchez-Busó, Michelle J. Cole, Rachel Pitt, Helen Fifer, Hamish Mohammed, Nigel Field, and Gwenda Hughes

Author affiliations: National Institute for Health Research, London, UK (K. Town, G. Hughes); Public Health England, London (K. Town, M.J. Cole, R. Pitt, H. Fifer, H. Mohammed, G. Hughes); University College London, London (K. Town, N. Field, G. Hughes); Microbiotica Ltd, Cambridge, UK (S. Harris); Wellcome Sanger Institute, Cambridge (S. Harris, L. Sánchez-Busó); University of Oxford, Oxford, UK (L. Sánchez-Busó)

Main Article

Association between antimicrobial susceptibility of Neisseria gonorrhoeae isolates and presence in lineage A of the phylogeny, England*

Susceptibility	Lineage A, no. isolates	Lineage B, no. isolates	aOR	95% CI	p value
Reduced
Ceftriaxone, MIC ≥0.015 mg/L
No	572	418	Referent	–	–
Yes	263	15	15.4	8.50–27.8	<0.001
Cefixime, MIC ≥0.03 mg/L
No	544	370	Referent	–	–
Yes	291	63	3.97	2.76–5.76	<0.001
Azithromycin, MIC ≥0.25 mg/L
No	328	367	Referent	–	–
Yes	507	66	7.50	5.37–10.5	<0.001
Resistant
Penicillin, MIC >1 mg/L or β-lactamase positive
No	671	378	Referent	–	–
Yes	164	55	1.33	0.92–1.93	0.134
Ciprofloxacin, MIC >0.06 mg/L
No	400	408	Referent	–	–
Yes	435	25	18.2	11.4–29.2	<0.001

*Each model adjusted for location inside or outside of London, and patient age, sexual orientation, and ethnicity. Nine isolates did not have MIC data. Bold text indicates statistical significance, i.e., p<0.05 and 95% CI does not cross 1. aOR, adjusted odds ratio.

Main Article

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Page updated: February 20, 2020

Page reviewed: February 20, 2020

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