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Volume 26, Number 3—March 2020

Mycobacterium tuberculosis Complex Lineage 3 as Causative Agent of Pulmonary Tuberculosis, Eastern Sudan1

Yassir A. ShuaibComments to Author , Eltahir A.G. Khalil, Lothar H. Wieler, Ulrich E. Schaible, Mohammed A. Bakheit, Saad E. Mohamed-Noor, Mohamed A. Abdalla, Glennah Kerubo, Sönke Andres, Doris Hillemann, Elvira Richter, Katharina Kranzer, Stefan Niemann2, and Matthias Merker2Comments to Author 
Author affiliations: Freie Universität Berlin, Berlin, Germany (Y.A. Shuaib, L.H. Wieler); Research Center Borstel, Borstel, Germany (Y.A. Shuaib, U.E. Schaible, S. Andres, D. Hillemann, S. Niemann, M. Merker); Sudan University of Science and Technology, Khartoum, Sudan (Y.A. Shuaib, S.E. Mohamed-Noor, M.A. Abdalla); University of Khartoum, Khartoum, Sudan (E.A.G. Khalil, M.A. Bakheit); Robert Koch Institute, Berlin (L.H. Wieler); Kenyatta University, Nairobi, Kenya (G. Kerubo); Labor Limbach, Heidelberg, Germany (E. Richter); London School of Hygiene and Tropical Medicine, London, UK (K. Kranzer); German Center for Infection Research, Borstel Site, Borstel (S. Niemann, M. Merker)

Main Article

Table 4

Performance of genotypic drug resistance prediction to first-line tuberculosis drugs in Mycobacterium tuberculosis complex strains, eastern Sudan*

Drug Resistant
Se, %† (95% CI) Sp, %‡ (95% CI) PPV, %§ (95% CI) NPV, %¶ (95% CI) Unknown mutations (%)
gR (TP) gS (FN) gU (FN) gR (FP) gS (TN) gU (TN)
SM 24 0 9 0 133 0 72.7 
(54.5–86.7) 100 100 93.7 
(89.4–96.3) 9/166 (5.4)
INH 17 0 0 0 149 0 100 100 100 100 0/166 (0.0)
RIF 17 0 0 0 149 0 100 100 100 100 0/166 (0.0)
EMB 1 0 0 10* 155 0 100 93.9 
(89.1–97.1) 9.10 
(5.2–15.4) 100 0/166 (0.0)
PZA 1 0 0 0 165 0 100 100 100 100 0/166 (0.0)

*See MICs in the Methods section. EMB, ethambutol; FN, false negative; FP, false positive; gR, genetically resistant; gS, genetically susceptible; gU, genetic resistance unknown; INH, isoniazid; NPV, negative predictive value; PPV, positive predictive value; PZA, pyrazinamide; RIF, rifampin; Se, sensitivity; Sp, specificity; SM, streptomycin; TN, true negative; TP, true positive.
†Se = TP ÷ TP + FN.
‡Sp = TN ÷ TN + FP.
§PPV =  TP ÷ (TP + FP).
¶NPV =  TN ÷ (TN + FN).

Main Article

1Preliminary results from this study were presented at the 39th Annual Congress of the European Society of Mycobacteriology, July 1–4, 2018, Dresden, Germany.

2These authors contributed equally to this article.

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