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Volume 26, Number 3—March 2020
Research

Acquisition of Plasmid with Carbapenem-Resistance Gene blaKPC2 in Hypervirulent Klebsiella pneumoniae, Singapore

Yahua Chen, Kalisvar Marimuthu, Jeanette Teo, Indumathi Venkatachalam, Benjamin Pei Zhi Cherng, Liang De Wang, Sai Rama Sridatta Prakki, Weizhen Xu, Yi Han Tan, Lan Chi Nguyen, Tse Hsien Koh, Oon Tek Ng, and Yunn-Hwen GanComments to Author 
Author affiliations: National University of Singapore, Singapore (Y. Chen, Y.H. Tan, L.C. Nguyen, Y.-H. Gan); National Centre for Infectious Diseases, Singapore (K. Marimuthu, L.D. Wang, S.R.S. Prakki, W. Xu, O.T. Ng); Tan Tock Seng Hospital, Singapore (K. Marimuthu, O.T. Ng); National University Hospital, Singapore (J. Teo); Singapore General Hospital, Singapore (I. Venkatachalam, B.P.Z. Cherng, T.H. Koh); Nanyang Technological University, Singapore (O.T. Ng)

Main Article

Table 1

Classifications and virulence characteristics of 18 carbapenem-resistant Klebsiella pneumoniae isolates harboring KPVP-associated genes, Singapore, 2013–2015*

Isolate Patient no. K locus ST Virulence score Locus
Yersiniabactin Colibactin Aerobactin Salmochelin rmpA rmpA2
ENT494 A2 1 23 5 ybt 1, ICEKP10 clb 2 iuc 1 iro 1 2(KPVP-1) 6
ENT646 A2 1 23 5 ybt 1, ICEKP10 clb 2 iuc 1 iro 1 2(KPVP-1) 6
ENT1734 A2 1 23 5 ybt 1, ICEKP10 clb 2 iuc 1 iro 1 2(KPVP-1) 6
ENT1061 A4 1 23 5 ybt 1, ICEKP10 clb 2 iuc 1 iro 1 2(KPVP-1) 6
ENT1256 A6 1 23 5 ybt 1, ICEKP10 clb 2 iuc 1 iro 1 2(KPVP-1) 5
ENT1332 A8 20 893 4 ybt unknown – iuc 1 iro 1 1(KPVP-1) 2
ENT1381 A12 20 420 4 ybt 9, ICEKP3 – iuc 1 iro 1 1(KPVP-1) 5
ENT1192 A14 2 86 4 ybt 9, ICEKP3 – iuc 1 iro 1 2(KPVP-1) 6
ENT1988 A14 2 86 4 ybt 9, ICEKP3 – iuc 1 iro 1 2(KPVP-1) 6
ENT596 A15 2 65 5 ybt 17, ICEKP10 clb 3 iuc 1 iro 1 2(KPVP-1) 6
ENT607 A15 2 65 5 ybt 17, ICEKP10 clb 3 iuc 1 iro 1 2(KPVP-1) 6
ENT686 A15 2 65 5 ybt 17, ICEKP10 clb 3 iuc 1 iro 1 2(KPVP-1) 6
ENT715 A15 2 65 5 ybt 17, ICEKP10 clb 3 iuc 1 iro 1 2(KPVP-1) 6
ENT750 A15 2 65 5 ybt 17, ICEKP10 clb 3 iuc 1 iro 1 2(KPVP-1) 6
ENT758 A15 2 65 5 ybt 17, ICEKP10 clb 3 iuc 1 iro 1 2(KPVP-1) 6
ENT883 A15 2 65 5 ybt 17, ICEKP10 clb 3 iuc 1 iro 1 2(KPVP-1) 6
ENT1072 A15 2 65 5 ybt 17, ICEKP10 clb 3 iuc 1 iro 1 2(KPVP-1) 6
ENT1077 A15 2 65 5 ybt 17, ICEKP10 clb 3 iuc 1 iro 1 2(KPVP-1) 6
ENT495† 66 841 0 – – – – – –
SGH10‡ 1 23 5 ybt 1, ICEKP10 clb 2 iuc 1 iro 1 2(KPVP-1) 6
CG43§ 2 86 3 – – iuc 1 iro 1 1(KPVP-1) 1

*ICEKP, integrative conjugative element K. pneumoniae; KPVP, K. pneumoniae virulence plasmid; ST, sequence type.
†Control carbapenem-resistant K. pneumoniae isolate (classified as K. quasipneumoniae by GenBank).
‡GenBank accession nos. CP025080 and CP025081.
§GenBank accession nos. CP006648 and AY378100.

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Page created: February 20, 2020
Page updated: February 20, 2020
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