Volume 26, Number 3—March 2020
Research
Acquisition of Plasmid with Carbapenem-Resistance Gene blaKPC2 in Hypervirulent Klebsiella pneumoniae, Singapore
Yahua Chen, Kalisvar Marimuthu, Jeanette Teo, Indumathi Venkatachalam, Benjamin Pei Zhi Cherng, Liang De Wang, Sai Rama Sridatta Prakki, Weizhen Xu, Yi Han Tan, Lan Chi Nguyen, Tse Hsien Koh, Oon Tek Ng, and Yunn-Hwen Gan
Table 2
Isolation date, sampling site, and resistance genes of carbapenem-resistant hypervirulent Klebsiella pneumoniae isolates, Singapore, 2013–2015
| Isolate | Patient no. | Date of isolation | Sampling site | β-lactam resistance genes | Other resistance genes |
|---|---|---|---|---|---|
| ENT494 | A2 | 2013 Jun 7 | Sputum | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A) |
| ENT646 | A2 | 2013 Sep 18 | Blood | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B, blaOXA-1 | oqxA, oqxB, fosA6, mph(A), qnrB1, aac(6')-lb-cr, catB3, dfrA14 |
| ENT1734 | A2 | 2014 Dec 19 | Rectum | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B, blaOXA-1 | oqxA, oqxB, fosA6, mph(A), catB3, aac(6')-lb-cr |
| ENT1061 | A4 | 2014 Mar 13 | Blood | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A) |
| ENT1256 | A6 | 2014 Jun 20 | Rectum | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A) |
| ENT1332 | A8 | 2014 Jul 13 | Rectum | blaSHV-1, blaKPC-2, blaTEM-1A, blaTEM-1B, blaCTX-M-15 | oqxA, oqxB, fosA6, mph(A), aac(6')-lb-cr, aadA16, qnrB6, arr-3, sul1, tet(A), dfrA27 |
| ENT1381 | A12 | 2014 Aug 10 | Midstream urine | blaSHV-75, blaKPC-2, blaTEM-1A, blaTEM-1B, blaOXA-1 | oqxA, oqxB, fosA6, mph(A) |
| ENT1192 | A14 | 2014 May 24 | Rectum | blaSHV-1, blaKPC-2, blaTEM-1A, blaTEM-1B, blaOXA-1 | oqxA, oqxB, fosA5, mph(A), aac(6')-lb-cr, qnrB1, catB3, tet(A), dfrA14 |
| ENT1988 | A14 | 2015 Apr 16 | Feces, rectum | blaSHV-1, blaKPC-2, blaTEM-1A, blaTEM-1B, blaOXA-1 | oqxA, oqxB, fosA5, mph(A), aac(6')-lb-cr, qnrB1, catB3, tet(A), dfrA14 |
| ENT596 | A15 | 2013 Aug 22 | Urine | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A) |
| ENT607 | A15 | 2013 Aug 22 | Sputum | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A), aadA1, cmlA1, arr-2, sul1 |
| ENT686 | A15 | 2013 Oct 4 | Tracheostomy aspirate | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | fosA6, mph(A) |
| ENT715 | A15 | 2013 Oct 17 | Trachea aspirate | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A) |
| ENT750 | A15 | 2013 Oct 31 | Blood | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A) |
| ENT758 | A15 | 2013 Oct 31 | Tracheal aspirate | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A) |
| ENT883 | A15 | 2013 Dec 14 | Sputum | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A) |
| ENT1072 | A15 | 2014 Mar 26 | Sputum | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A) |
| ENT1077 | A15 | 2014 Mar 28 | Rectum | blaSHV-11, blaKPC-2, blaTEM-1A, blaTEM-1B | oqxA, oqxB, fosA6, mph(A), tet(A), dfrA14 |
| ENT495* | 2013 Jun 8 | Not known | blaOKP-B-6, blaKPC-2, blaTEM-1A, blaTEM-1B, blaOXA-1 | oqxA, oqxB, fosA6, mph(A), tet(A), dfrA14, aac(6')-Ib-cr, aadA1, arr-2, cmlA5, ereA, qnrB1, sul1 | |
| SGH10 | Not applicable | Blood | blaSHV-11 | oqxA, oqxB, fosA6 |
*Control carbapenem-resistant K. pneumoniae isolate (classified as K. quasipneumoniae by GenBank).
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