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Volume 26, Number 3—March 2020

Mycobacterium tuberculosis Beijing Lineage and Risk for Tuberculosis in Child Household Contacts, Peru

Chuan-Chin Huang1, Alexander L. Chu1, Mercedes C. Becerra, Jerome T. Galea, Roger Calderón, Carmen Contreras, Rosa Yataco, Zibiao Zhang, Leonid Lecca, and Megan B. MurrayComments to Author 
Author affiliations: Brigham and Women’s Hospital, Boston, Massachusetts, USA (C.-C. Huang, M.C. Becerra, Z. Zhang, M.B. Murray); Harvard Medical School, Boston (C.-C. Huang, M.C. Becerra, M.B. Murray); Harvard University Division of Continuing Education, Cambridge, Massachusetts, USA (A.L. Chu); University of South Florida, Tampa, Florida, USA (J.T. Galea); Socios En Salud Sucursal, Lima, Peru (R. Calderon, C. Contreras, R. Yataco, L. Lecca)

Main Article

Table 5

Hazard ratios of tuberculin skin test conversion comparing contacts exposed to a Mycobacterium tuberculosis Beijing lineage with those exposed to a non-Beijing lineage, Lima, Peru, September 2009–August 2012

Lineage Age <15 y*
Age >15 y*
Incidence, %† Hazard ratio (95% CI)
Incidence, %† Hazard ratio (95% CI)
Univariate Multivariate‡ Univariate Multivariate‡
Non-Beijing 0.26 (356/1,396) Referent Referent 0.69 (845/1,236) Referent Referent
Beijing 0.39 (62/160) 1.53 (1.09–2.14) 1.65 (1.17–2.33) 0.73 (118/162) 1.02 (0.80–1.30) 1.03 (0.80–1.33)

*Likelihood ratio test for the interaction between age (<15 or >15 y) and index patient M. tuberculosis lineage: p = 0.048.
†Per person-year for the univariate model.
‡Adjusted for index patient drug resistance profile; index patient age (16–30, 31–45, 46–60, and >60 y); index patient HIV status; household contact age (0–5, 6–10, 11–15, 16–30, 31–45, 46–60, and >60 y); household contact M. bovis BCG vaccination status; household contact socioeconomic status; household contact nutritional status.

Main Article

1These authors contributed equally to this article.

Page created: February 20, 2020
Page updated: February 20, 2020
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