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Volume 26, Number 3—March 2020
Research

Risk Factors for Complicated Lymphadenitis Caused by Nontuberculous Mycobacteria in Children

Martin Kuntz, Daniela S. Kohlfürst, Cornelia Feiterna-Sperling, Renate Krüger, Ulrich Baumann, Laura Buchtala, Roland Elling, Veit Grote, Johannes Hübner, Markus Hufnagel, Petra Kaiser-Labusch, Johannes Liese, Eva-Maria Otto, Markus A. Rose1, Christian Schneider, Volker Schuster, Maximilian Seidl, Olaf Sommerburg, Markus Vogel2, Horst von Bernuth, Michael Weiß, Theodor Zimmermann, Alexandra Nieters, Werner Zenz, Philipp HennekeComments to Author , and for the NTMkids Consortium
Author affiliations: University of Freiburg, Freiburg, Germany (M. Kuntz, R. Elling, M. Hufnagel, C. Schneider, M. Seidl, A. Nieters, P. Henneke); Medical University of Graz, Graz, Austria (D.S. Kohlfürst, W. Zenz); Charité–Universitätsmedizin Berlin, Berlin, Germany (C. Feiterna-Sperling, R. Krüger, H. von Bernuth); Hannover Medical School, Hannover, Germany (U. Baumann); Professor-Hess-Kinderklinik, Bremen, Germany (L. Buchtala, P. Kaiser-Labusch); Dr. von Hauner Children's Hospital, Munich, Germany (V. Grote, J. Hübner); University Children’s Hospital, Würzburg, Germany (J. Liese); Children’s Hospital, Cologne, Germany (E.-M. Otto, M. Weiß); Goethe University of Frankfurt, Frankfurt, Germany (M.A. Rose); University of Leipzig, Leipzig, Germany (V. Schuster); University of Heidelberg, Heidelberg, Germany (O. Sommerburg); Heinrich Heine University, Düsseldorf, Germany (M. Vogel); Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany (T. Zimmermann)

Main Article

Table 2

Patient characteristics, treatment, and outcome for cases of complicated lymphadenitis caused by nontuberculous mycobacteria across 13 centers in Germany and Austria*

Characteristics Total Participating center
 p value†
A B C D
Patient sex, no. (%) 138 47 35 27 29 NS
F 84 (60.9) 29 (61.7) 21 (60) 15 (55.6) 18 (62.1) NS
M
 54 (39.1)
 18 (38.3)
 14 (40)
 12 (44.4)
 11 (37.9)
 NS
Median patient age, mo
 28
 28
 27
 27
 37
 NS
Treatment, %
Surgery 94 100 91 89 92 NS
Complete extirpation 49 48 69 42 32 0.03
Antimycobacterial therapy
 44
 62
 21
 30
 55
 <0.001
Outcome, %
Unfavorable 65 41 68 74 90 0.006
Impaired wound healing 25 19 17 37 34 NS
Facial nerve palsy
 7
 2
 6
 0
 24
 0.002
Mean risk score‡ 2.3 1.9 2.6 2.8 2.3 0.004

*Combined data from 10 smaller centers are represented in A and the 3 largest centers are represented by B, C, and D. NS, not significant.
†p values are based on original count data and calculated by using the Fisher exact test.
‡Risk scores calculated by using the Kruskal-Wallis test.

Main Article

1Current affiliation: Olga Children’s Hospital, Stuttgart, Germany.

2Current affiliation: Hospital Neuwerk, Mönchengladbach, Germany.

Page created: February 20, 2020
Page updated: February 20, 2020
Page reviewed: February 20, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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