Figure 1. Serotype changes in Streptococcus pneumoniae strains isolated in Taiwan, 2013–2017. The prevalence of strains with an MIC >0.06 mg/L for penicillin was sustained during the study. PCV7 and PCV13–non-PCV7 serotypes decreased (p = 0.009) over time. In contrast, PPV23 serotypes and the non-PCV13 serotypes 15B/C increased (p = 0.002) and the rate of serotype 15A fluctuated. PCV7, 7-valent pneumococcal conjugate vaccine; PCV13, 13-valent pneumococcal conjugate vaccine; PPV23, 23-valent pneumococcal polysaccharide vaccine; PEN, penicillin; MEM, meropenem.