Volume 26, Number 4—April 2020
Research
Genomic Insight into the Spread of Meropenem-Resistant Streptococcus pneumoniae Spain23F-ST81, Taiwan
Yi-Yin Chen1, Yu-Chia Hsieh1
, Yu-Nong Gong, Wei-Chao Liao, Shiao-Wen Li, Ian Yi-Feng Chang, Tzu-Lung Lin, Ching-Tai Huang, Cheng-Hsiu Chiu, Tsu-Lan Wu, Lin-Hui Su, Ting-Hsuan Li, and Ya-Yu Huang
, Yu-Nong Gong, Wei-Chao Liao, Shiao-Wen Li, Ian Yi-Feng Chang, Tzu-Lung Lin, Ching-Tai Huang, Cheng-Hsiu Chiu, Tsu-Lan Wu, Lin-Hui Su, Ting-Hsuan Li, and Ya-Yu Huang
Table 3
Antimicrobial resistance genes and Tn916-like transposon gene in 24 meropenem-nonsusceptible Streptococcus pneumoniae 15B/C-ST83 clinical isolates*
| Isolate name, serotype | PBP profile 1a:2b:2x | Antimicrobial resistance genes |
||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| tetM | tetO | ermB | ermTR | mef (A/E) | Tn of Tn916-like | cat | CFT | Mutations |
||||||||||
| MIC, mg/L |
folA† | folP‡ | gyrA | gyrB | parC§ | parE | rpoB | |||||||||||
| PEN | MEM | |||||||||||||||||
| 2013 | ||||||||||||||||||
| B1136, 15C | 1 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
| B999-49, 15B | 1 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
| B1300936, 15C |
2 |
0.5 |
15:12:18 |
+ |
− |
+ |
− |
− |
Tn6002 |
+ |
R |
+ |
+ |
− |
− |
− |
− |
− |
| 2014 | ||||||||||||||||||
| 1018-71,15B | 2 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
| 1025-08, 15B | 2 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
| 1054-32, 15C |
2 |
0.5 |
15:12:18 |
+ |
− |
+ |
− |
− |
Tn6002 |
+ |
R |
+ |
+ |
− |
− |
− |
− |
− |
| 2016 | ||||||||||||||||||
| B1675, 15B | 2 | 1 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
| B0236, 15B | 2 | 1 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
| 1148-64, 15C | 2 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
| 1217-52, 15B | 1 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
| K54, 15B | 2 | 1 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
| K55, 15B |
2 |
1 |
15:12:18 |
+ |
− |
+ |
− |
− |
Tn6002 |
+ |
R |
+ |
+ |
− |
− |
− |
− |
− |
| 2017 | ||||||||||||||||||
| B2581, 15B | 2 | 1 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | + | − | − |
| B5939, 15B | 2 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | + | − | − |
| B4505, 15C | 2 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
| B1757, 15C | 2 | 1 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
| B3127, 15C | 2 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
| B2404, 15B | 2 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
| B8812, 15B | 2 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
| 1244-61, 15B | 2 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
| 1267-33, 15B | 2 | 1 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
| 1276-72, 15C | 2 | 1 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
| K72, 15B | 2 | 1 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
| K110, 15B | 4 | 1 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
*CFT, ceftriaxone; MEM, meropenem; PEN, penicillin; R, resistant; +, positive; −, negative.
†I100L substitution.
‡Insertion of 1 codon between bases 168 and 201.
§S79Y substitution.
1These first authors contributed equally to this article.
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