Volume 26, Number 4—April 2020
Research
Genomic Insight into the Spread of Meropenem-Resistant Streptococcus pneumoniae Spain23F-ST81, Taiwan
Table 3
Antimicrobial resistance genes and Tn916-like transposon gene in 24 meropenem-nonsusceptible Streptococcus pneumoniae 15B/C-ST83 clinical isolates*
Isolate name, serotype | PBP profile 1a:2b:2x | Antimicrobial resistance genes |
||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
tetM | tetO | ermB | ermTR | mef (A/E) | Tn of Tn916-like | cat | CFT | Mutations |
||||||||||
MIC, mg/L |
folA† | folP‡ | gyrA | gyrB | parC§ | parE | rpoB | |||||||||||
PEN | MEM | |||||||||||||||||
2013 | ||||||||||||||||||
B1136, 15C | 1 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
B999-49, 15B | 1 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
B1300936, 15C |
2 |
0.5 |
15:12:18 |
+ |
− |
+ |
− |
− |
Tn6002 |
+ |
R |
+ |
+ |
− |
− |
− |
− |
− |
2014 | ||||||||||||||||||
1018-71,15B | 2 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
1025-08, 15B | 2 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
1054-32, 15C |
2 |
0.5 |
15:12:18 |
+ |
− |
+ |
− |
− |
Tn6002 |
+ |
R |
+ |
+ |
− |
− |
− |
− |
− |
2016 | ||||||||||||||||||
B1675, 15B | 2 | 1 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
B0236, 15B | 2 | 1 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
1148-64, 15C | 2 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
1217-52, 15B | 1 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
K54, 15B | 2 | 1 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
K55, 15B |
2 |
1 |
15:12:18 |
+ |
− |
+ |
− |
− |
Tn6002 |
+ |
R |
+ |
+ |
− |
− |
− |
− |
− |
2017 | ||||||||||||||||||
B2581, 15B | 2 | 1 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | + | − | − |
B5939, 15B | 2 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | + | − | − |
B4505, 15C | 2 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
B1757, 15C | 2 | 1 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
B3127, 15C | 2 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
B2404, 15B | 2 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
B8812, 15B | 2 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
1244-61, 15B | 2 | 0.5 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
1267-33, 15B | 2 | 1 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
1276-72, 15C | 2 | 1 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
K72, 15B | 2 | 1 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
K110, 15B | 4 | 1 | 15:12:18 | + | − | + | − | − | Tn6002 | + | R | + | + | − | − | − | − | − |
*CFT, ceftriaxone; MEM, meropenem; PEN, penicillin; R, resistant; +, positive; −, negative.
†I100L substitution.
‡Insertion of 1 codon between bases 168 and 201.
§S79Y substitution.
1These first authors contributed equally to this article.