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Volume 26, Number 5—May 2020
Research

Nationwide Monitoring for Plasmodium falciparum Drug-Resistance Alleles to Chloroquine, Sulfadoxine, and Pyrimethamine, Haiti, 2016–2017

Eric Rogier, Camelia Herman, Curtis S. Huber, Karen E.S. Hamre, Baby Pierre, Kimberly E. Mace, Jacquelin Présumé, Gina Mondélus, Ithamare Romilus, Tamara Elismé, Thomas P. Eisele, Thomas Druetz, Alexandre Existe, Jacques Boncy, Jean F. Lemoine, Venkatachalam Udhayakumar, and Michelle A. ChangComments to Author 
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (E. Rogier, C. Herman, C.S. Huber, K.E.S. Hamre, K.E. Mace, V. Udhayakumar, M.A. Chang); Ministère de la Santé Publique et de la Population, Port-au-Prince, Haiti (B. Pierre, J. Présumé, G. Mondélus, I. Romilus, T. Elismé, A. Existe, J. Boncy, J.F. Lemoine); Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA (T.P. Eisele); University of Montreal School of Public Health, Montreal, Canada (T. Druetz)

Main Article

Table

Serum samples indicating putative malaria drug-resistance codon mutations for genes Pfcrt, Pfdhfr, and Pfdhps, by healthcare facility, Haiti, 2016–2017*

Site (no. samples) Pfcrt Pfdhfr
Pfdhps
C50R N51I C59R S108N I164L S436X‡
A437G
K540E A581G
A613X§
Arnaud (211) ND ND ND ND 132 (63) ND ND ND ND ND ND
Capotille (13) ND ND ND ND 1 (8) ND ND ND ND ND ND
Cazale (23) ND ND 1 (4) 1 (4) 13 (57) ND ND ND ND ND ND
Thienne/Dauphine (21) ND ND ND ND 14 (67) ND ND ND ND ND ND
Lavanneau (12) ND ND ND ND 1 (8) ND ND ND ND ND ND
Les Anglais (211) ND ND ND ND 27 (13) ND ND 1 (0.5) ND ND ND
Pignon (2) ND ND ND ND ND ND ND ND ND ND ND
Roseaux (68) ND ND ND ND 15 (22) ND ND ND ND ND ND
Sainte-Hélène (199) ND ND ND ND 53 (27) ND ND ND ND ND ND
Thomonde (18) ND ND ND ND 1 (6) ND ND ND ND ND ND
Total (778) ND ND 1 (0.2) 1 (0.2) 257 (47) ND ND 1 (0.2)
ND
ND
ND

*Values are no. (%) unless indicated. ND, not detected.
†Mutations in any of the Pfcrt C72S, M74I, N75E, or K76T codons.
‡S436A, S436Y, or S436F mutations.
§A613S or A613T mutations.

Main Article

Page created: April 16, 2020
Page updated: April 16, 2020
Page reviewed: April 16, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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