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Volume 26, Number 5—May 2020
Research Letter

Rise in Murine Typhus in Galveston County, Texas, USA, 2018

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Karla Ruiz, Randy Valcin, Philip Keiser, and Lucas S. BlantonComments to Author 
Author affiliations: Galveston County Health District, Texas City, Texas, USA (K. Ruiz, R. Valcin, P. Keiser); University of Texas Medical Branch, Galveston, Texas, USA (P. Keiser, L.S. Blanton)

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Murine typhus, an undifferentiated febrile illness caused by Rickettsia typhi, is increasing in prevalence and distribution throughout Texas. In 2018, a total of 40 cases of murine typhus were reported in Galveston County. This increase, unprecedented since the 1940s, highlights the importance of awareness by physicians and public health officials.

Murine typhus is an undifferentiated febrile illness endemic worldwide in tropical and subtropical seaboard regions, where rats and rat fleas (Xenopsylla cheopis) are involved in the maintenance and transmission of the etiologic agent, Rickettsia typhi (1). Once prevalent in the United States, the disease was nearly eradicated following vector control practices of the 1940s using DDT (2). In 2012, murine typhus was identified in 2 patients from Galveston, Texas. The identification of cases in a city where murine typhus was perceived to have been eliminated prompted the investigation and identification of 12 patients from Galveston County in 2013 (3). Since then, murine typhus has been reported to the Galveston County Health District (GCHD) yearly (1 case in 2014, 8 in 2015, 2 in 2016, and 17 in 2017). Murine typhus has also increased in prevalence and distribution throughout Texas (4). To call attention to this increasingly prevalent disease, we describe an increase of murine typhus reported to the GCHD in 2018.

In Texas, murine typhus is a reportable disease. Our data were collected as part of investigatory efforts of the GCHD to document typhus group rickettsioses (TGR) in Galveston County. The case definition for confirmed TGR includes a clinically compatible illness (acute onset of fever with >1 symptoms including headache, myalgia, anorexia, rash, nausea/vomiting, thrombocytopenia, and elevated hepatic transaminases) with 1 of the following: IgG seroconversion from acute- and convalescent-phase specimens, PCR amplification of R. typhi, immunohistochemical demonstration of the organism within tissue specimens, or culture isolation of R. typhi. We defined probable cases as those having an indirect immunofluorescence assay antibody titer of >1:128 during a compatible illness.

In 2018, a total of 40 cases (12 confirmed and 28 probable) were reported to the GCHD. All cases were considered as TGRs based on serology and were identified throughout the county, affecting persons from 8 cities (Dickinson, Friendswood, Galveston, Kemah, La Marque, League City, Santa Fe, Texas City) and 2 unincorporated areas (Appendix Figure). The city of Galveston reported the most cases (11, 28%). Although 1 case occurred in January, the others occurred during April–November, with the greatest numbers in June (8, 20%) and July (10, 25%). There was a male predominance (23, 58%) and the median age was 46.5 (range 4–87) years. Frequently reported signs and symptoms included fever (40, 100%), malaise (36, 90%), myalgias (34, 85%), headache (29, 73%), anorexia (22, 55%), nausea/vomiting (22, 55%), rash (20, 50%), and elevated hepatic transaminases (17, 43%) (Table). With the exception of more nausea/vomiting in probable cases, there were no differences in signs or symptoms between confirmed and probable cases. Thirty (75%) patients were hospitalized, and 2 (5%) required intensive care. Details of treatment were known in 35 cases (34 patients received doxycycline and 1 received ciprofloxacin). No deaths were reported. Flea exposure was reported frequently (22, 55%). Patients reported a variety of exposures to mammalian hosts for fleas (Table).

Murine typhus was once prevalent in the United States, with a peak of 5,401 cases in 1944. After eradication efforts using DDT were implemented in 1945, incidence plummeted (e.g., 98 cases in 1956) (2). In the decades that followed, parts of southern California and the most southern counties of Texas remained endemic. In these areas, a transmission cycle involving opossums (Didelphis virginiana) and cat fleas (Ctenocephalides felis) was suspected (1). After the recognized reemergence of murine typhus in Galveston, studies have demonstrated that 67% of opossums are seroreactive and 7% of C. felis fleas collected from these animals are infected with R. typhi (5). In contrast, only 0.3% of C. felis fleas collected from feral cats are infected (6). Although the detailed reservoir–vector dynamics involved with the increasing distribution of R. typhi are yet to be elucidated, the broad geographic range of opossums in North America and the ubiquity of cat fleas parasitizing opossums (7) cause concern for the spread of murine typhus to areas not yet endemic.

The increase in reported cases may be related not only to ecologic factors but also to increased recognition by physicians and enhanced surveillance. Indeed, murine typhus is well recognized at the University of Texas Medical Branch (UTMB), the largest healthcare system in Galveston County. Furthermore, murine typhus is now recognized as a cause of fever in local children. In a study performed at UTMB during 2012–2016, no pediatric patients had yet been identified (8). The later recognition in the pediatric age group was spurred in part by a pediatric case in the fall of 2017, which occurred after local education efforts. Two recently published case series of murine typhus in children may have also contributed (9,10). Finally, since September 2017, the GCHD has distributed several email advisories alerting local physicians of murine typhus.

The rise of murine typhus in Galveston is in step with the apparent increase in distribution across Texas. Awareness of this difficult to recognize undifferentiated febrile illness is paramount not only within Texas but also in other parts of the United States where opossums and cat fleas are distributed.

Ms. Ruiz is an epidemiologist at the Galveston County Health District, Texas City, Texas, USA. Her research interest is in the epidemiology of infectious diseases.



We thank David H. Walker for his thoughtful review and advice.

L.B. is supported by the Institute for Translational Sciences at the University of Texas Medical Branch, supported in part by a CTSA Mentored Career Development (KL2) Award (KL2TR001441) from the National Center for Advancing Translational Sciences, National Institutes of Health.



  1. Azad  AF, Radulovic  S, Higgins  JA, Noden  BH, Troyer  JM. Flea-borne rickettsioses: ecologic considerations. Emerg Infect Dis. 1997;3:31927. DOIPubMedGoogle Scholar
  2. Pratt  HD. The changing picture of murine typhus in the United States. Ann N Y Acad Sci. 1958;70:51627. DOIPubMedGoogle Scholar
  3. Blanton  LS, Vohra  RF, Bouyer  DH, Walker  DH. Reemergence of murine typhus in Galveston, Texas, USA, 2013. Emerg Infect Dis. 2015;21:4846. DOIPubMedGoogle Scholar
  4. Murray  KO, Evert  N, Mayes  B, Fonken  E, Erickson  T, Garcia  MN, et al. Typhus group rickettsiosis, Texas, USA, 2003–2013. Emerg Infect Dis. 2017;23:6458. DOIPubMedGoogle Scholar
  5. Blanton  LS, Idowu  BM, Tatsch  TN, Henderson  JM, Bouyer  DH, Walker  DH. Opossums and cat fleas: new insights in the ecology of murine typhus in Galveston, Texas. Am J Trop Med Hyg. 2016;95:45761. DOIPubMedGoogle Scholar
  6. Blanton  LS, Vohra  RF, Fistein  L, Quade  B, Walker  DH, Bouyer  DH. Rickettsiae within the fleas of feral cats in Galveston, Texas. Vector Borne Zoonotic Dis. 2019;19:64751. DOIPubMedGoogle Scholar
  7. Rust  MK. The biology and ecology of cat fleas and advancements in their pest management: A review. Insects. 2017;8:E118. DOIPubMedGoogle Scholar
  8. Vohra  RF, Walker  DH, Blanton  LS. Analysis of health-care charges in murine typhus: need for improved clinical recognition and diagnostics for acute disease. Am J Trop Med Hyg. 2018;98:15948. DOIPubMedGoogle Scholar
  9. Erickson  T, da Silva  J, Nolan  MS, Marquez  L, Munoz  FM, Murray  KO. Newly recognized pediatric cases of typhus group rickettsiosis, Houston, Texas, USA. Emerg Infect Dis. 2017;23:206871. DOIPubMedGoogle Scholar
  10. Howard  A, Fergie  J. Murine typhus in South Texas children: an 18-year review. Pediatr Infect Dis J. 2018;37:10716. DOIPubMedGoogle Scholar




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DOI: 10.3201/eid2605.191505

Original Publication Date: April 09, 2020

Table of Contents – Volume 26, Number 5—May 2020

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Please use the form below to submit correspondence to the authors or contact them at the following address:

Lucas S. Blanton, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-0435, USA

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