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Volume 26, Number 6—June 2020
Research

Characterization of Sporadic Creutzfeldt-Jakob Disease and History of Neurosurgery to Identify Potential Iatrogenic Cases

Tsuyoshi Hamaguchi, Kenji Sakai, Atsushi Kobayashi, Tetsuyuki Kitamoto, Ryusuke Ae, Yosikazu Nakamura, Nobuo Sanjo, Kimihito Arai, Mizuho Koide, Fumiaki Katada, Masafumi Harada, Hiroyuki Murai, Shigeo Murayama, Tadashi Tsukamoto, Hidehiro Mizusawa, and Masahito YamadaComments to Author 
Author affiliations: Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan (T. Hamaguchi, K. Sakai, M. Yamada); Hokkaido University, Sapporo, Japan (A. Kobayashi); Tohoku University Graduate School of Medicine, Sendai, Japan (T. Kitamoto); Jichi Medical University, Shimotsuke, Japan (R. Ae, Y. Nakamura); Tokyo Medical and Dental University, Tokyo, Japan (N. Sanjo); National Hospital Organization Chiba-East Hospital, Chiba, Japan (K. Arai, M. Koide); Kameda Medical Center, Chiba (F. Katada); The University of Tokushima, Tokushima, Japan (M. Harada); International University of Health and Welfare, Narita, Japan (H. Murai); Tokyo Metropolitan Institute of Gerontology, Tokyo (S. Murayama); National Center of Neurology and Psychiatry, Kodaira, Japan (T. Tsukamoto, H. Mizusawa)

Main Article

Table 3

Patients without history of neurosurgery who had no periodic sharp-wave complexes during duration of CJD and hyperintensity lesions in thalamus diffusion-weighted magnetic resonance imaging of the brain*

Patient no. Age at CJD onset, y/sex Codon 129 of PRNP Hyperintensity lesions on DW-MRI Pathology findings
1 58/F MM CC, BG, Th MM2+1
2 65/M MM CC, Th MM2+1
3 61/F MM CC, BG, Th ND
4 58/M MV BG, Th MV2
5 73/F MV CC, Th MV2
6 65/F MV CC, BG, Th ND
7 65/F MV CC, Th ND
8 75/F VV BG, Th VV2
9 69/M VV BG, Th VV2
10
 52/M
 VV
 CC, BG, Th
 ND
*BG, basal ganglia; CC, cerebral cortex; CJD, Creutzfeldt-Jakob disease; DW-MRI, diffusion-weighted magnetic resonance imaging; MM, methionine homozygous; MM2+1, pathological features of MM2 and MM1 types of sporadic CJD; MV, methionine-valine; Th, thalamus; VV, valine homozygous.

Main Article

Page created: May 18, 2020
Page updated: May 18, 2020
Page reviewed: May 18, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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