TY - JOUR AU - Faye, Oumar AU - de Lourdes Monteiro, Maria AU - Vrancken, Bram AU - Prot, Matthieu AU - Lequime, Sebastian AU - Diarra, Maryam AU - Ndiaye, Oumar AU - Valdez, Tomas AU - Tavarez, Sandra AU - Ramos, Jessica AU - da Veiga Leal, Silvânia AU - Pires, Cecilio AU - Moreira, Antonio AU - Tavares, Maria Filomena AU - Fernandes, Linete AU - Barreto, Jorge Noel AU - do Céu Teixeira, Maria AU - de Lima Mendonça, Maria da Luz AU - Gomes, Carolina Cardoso da Silva Leite AU - Castellon, Mariano Salazar AU - Ma, Laurence AU - Lemoine, Frédéric AU - Gámbaro-Roglia, Fabiana AU - Delaune, Déborah AU - Fall, Gamou AU - Fall, Ibrahima Socé AU - Diop, Mamadou AU - Sakuntabhai, Anavaj AU - Loucoubar, Cheikh AU - Lemey, Philippe AU - Holmes, Edward AU - Faye, Ousmane AU - Sall, Amadou Alpha AU - Simon-Loriere, Etienne T1 - Genomic Epidemiology of 2015–2016 Zika Virus Outbreak in Cape Verde T2 - Emerging Infectious Disease journal PY - 2020 VL - 26 IS - 6 SP - 1084 SN - 1080-6059 AB - During 2015–2016, Cape Verde, an island nation off the coast of West Africa, experienced a Zika virus (ZIKV) outbreak involving 7,580 suspected Zika cases and 18 microcephaly cases. Analysis of the complete genomes of 3 ZIKV isolates from the outbreak indicated the strain was of the Asian (not African) lineage. The Cape Verde ZIKV sequences formed a distinct monophylogenetic group and possessed 1–2 (T659A, I756V) unique amino acid changes in the envelope protein. Phylogeographic and serologic evidence support earlier introduction of this lineage into Cape Verde, possibly from northeast Brazil, between June 2014 and August 2015, suggesting cryptic circulation of the virus before the initial wave of cases were detected in October 2015. These findings underscore the utility of genomic-scale epidemiology for outbreak investigations. KW - Zika virus KW - microcephaly KW - Cabo Verde KW - Cape Verde KW - Brazil KW - Western Africa KW - genomics KW - disease outbreaks KW - epidemiologic studies KW - phylogeography KW - epidemiology KW - outbreak KW - viruses KW - vector-borne infections KW - serology KW - West Africa KW - Asian lineage DO - 10.3201/eid2606.190928 UR - https://wwwnc.cdc.gov/eid/article/26/6/19-0928_article ER - End of Reference