TY - JOUR AU - Rodriguez, Christophe AU - Gricourt, Guillaume AU - Ndebi, Melissa AU - Demontant, Vanessa AU - Poiteau, Lila AU - Burrel, Sonia AU - Boutolleau, David AU - Woerther, Paul-Louis AU - Calvez, Vincent AU - Stroer, Sebastian AU - Pawlotsky, Jean-Michel T1 - Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France T2 - Emerging Infectious Disease journal PY - 2020 VL - 26 IS - 6 SP - 1287 SN - 1080-6059 AB - We report the discovery of a new orthobunyavirus, Cristoli virus, by means of shotgun metagenomics. The virus was identified in an immunodepressed patient with fatal encephalitis. Full-length genome sequencing revealed high-level expression of a virulence factor, possibly explaining the severity of the infection. The patient’s recent history suggests circulation in France. KW - orthobunyavirus KW - shotgun metagenomics KW - encephalitis KW - viruses KW - Cristoli virus KW - France KW - meningitis/encephalitis DO - 10.3201/eid2606.191431 UR - https://wwwnc.cdc.gov/eid/article/26/6/19-1431_article ER - End of Reference