TY - JOUR AU - Hang, Jun AU - Kajon, Adriana AU - Graf, Paul C. F. AU - Berry, Irina Maljkovic AU - Yang, Yu AU - Sanborn, Mark AU - Fung, Christian AU - Adhikari, Anima AU - Balansay-Ames, Melinda AU - Myers, Christopher AU - Binn, Leonard AU - Jarman, Richard AU - Kuschner, Robert AU - Collins, Natalie T1 - Human Adenovirus Type 55 Distribution, Regional Persistence, and Genetic Variability T2 - Emerging Infectious Disease journal PY - 2020 VL - 26 IS - 7 SP - 1497 SN - 1080-6059 AB - Human adenovirus type 55 (HAdV-55) causes acute respiratory disease of variable severity and has become an emergent threat in both civilian and military populations. HAdV-55 infection is endemic to China and South Korea, but data from other regions and time periods are needed for comprehensive assessment of HAdV-55 prevalence from a global perspective. In this study, we subjected HAdV-55 isolates from various countries collected during 1969–2018 to whole-genome sequencing, genomic and proteomic comparison, and phylogenetic analyses. The results show worldwide distribution of HAdV-55; recent strains share a high degree of genomic homogeneity. Distinct strains circulated regionally for several years, suggesting persistent local transmission. Several cases of sporadic introduction of certain strains to other countries were documented. Among the identified amino acid mutations distinguishing HAdV-55 strains, some have potential impact on essential viral functions and may affect infectivity and transmission. KW - adenovirus KW - acute respiratory disease KW - emerging infectious disease KW - genetic variation KW - whole genome sequencing KW - viruses KW - United States DO - 10.3201/eid2607.191707 UR - https://wwwnc.cdc.gov/eid/article/26/7/19-1707_article ER - End of Reference