Volume 26, Number 7—July 2020
Dispatch
Possible Bat Origin of Severe Acute Respiratory Syndrome Coronavirus 2
Susanna K.P. Lau1
, Hayes K.H. Luk1, Antonio C.P. Wong1, Kenneth S.M. Li, Longchao Zhu, Zirong He, Joshua Fung, Tony T.Y. Chan, Kitty S.C. Fung, and Patrick C.Y. Woo
, Hayes K.H. Luk1, Antonio C.P. Wong1, Kenneth S.M. Li, Longchao Zhu, Zirong He, Joshua Fung, Tony T.Y. Chan, Kitty S.C. Fung, and Patrick C.Y. Woo
Table 2
Percentage amino acid identity between 7 conserved domains of the replicase polyprotein for species demarcation in SARS-CoV-2 and selected members of the subgenus Sarbecovirus*
| Virus | % Amino acid identity compared with that for SARS-CoV-2 |
|||||||
|---|---|---|---|---|---|---|---|---|
| ADRP | nsp5 | nsp12 | nsp13 | nsp14 | nsp15 | nsp16 | Seven concatenated domains | |
| Human SARS-CoV TOR2/Toronto/Mar2003 | 79.3 | 96.1 | 96.4 | 99.8 | 95.1 | 88.7 | 93.3 | 95.0 |
| Civet SARS-CoV SZ3/Shenzhen/2013 | 79.3 | 96.1 | 96.4 | 99.7 | 95.1 | 88.7 | 93.6 | 95.0 |
| Civet SARS-CoV PC4–136/Guangdong/2004 | 78.4 | 96.1 | 96.4 | 99.3 | 94.7 | 88.7 | 93.3 | 94.8 |
| Human SARS-CoV GZ0402 | 78.4 | 95.8 | 96.2 | 99.5 | 94.9 | 51.7 | 93.3 | 94.8 |
| SARSr-Rs-BatCoV HKU3–1/R.sinicus/Hong Kong/2005 | 79.3 | 95.4 | 95.6 | 98.8 | 94.7 | 88.2 | 93.3 | 94.5 |
| SARSr-Rp-BatCoV Rp/Shaanxi2011/R.pusillus/Shaanxi/2011 | 78.4 | 96.1 | 96.1 | 99.3 | 96.0 | 88.4 | 93.6 | 95.0 |
| SARSr-Rs-BatCoV Rs672/2006/R.sinicus/Guizhou/2006 | 80.2 | 95.4 | 96.5 | 99.0 | 95.6 | 88.2 | 94.3 | 95.0 |
| SARSr-Rs-BatCoV WIV1 | 80.2 | 95.8 | 96.2 | 99.5 | 95.4 | 89.0 | 93.0 | 95.0 |
| SARSr-Rf-BatCoV YNLF_31C/R.ferrumequinum/Yunnan/2013 | 80.2 | 95.8 | 96.2 | 99.3 | 95.6 | 88.7 | 93.0 | 95.0 |
| SARSr-Rf-BatCoV 16BO133/R.ferrumequinum/Korea/2016 | 79.3 | 95.1 | 96.1 | 98.7 | 94.9 | 88.2 | 92.6 | 94.6 |
| SARSr-Rf-BatCoV JTMC15/R.ferrumequinum/Jilin/2013 | 79.3 | 94.8 | 96.2 | 98.5 | 94.9 | 88.2 | 92.6 | 94.5 |
| SARSr-Rs-BatCoV BtKY72/Rhinolophus sp./Kenya/2007 | 74.8 | 95.4 | 95.0 | 96.8 | 92.8 | 87.3 | 90.6 | 92.9 |
| SARSr-Rm-BatCoV Longquan-140/R.monoceros/Zhejiang/2012 | 79.3 | 95.8 | 95.7 | 99.2 | 94.9 | 89.0 | 94.3 | 94.8 |
| SARSr-Rb-BatCoV BM48–31/BGR/2008/R.blasii/Bulgaria/2008 | 78.4 | 94.1 | 95.2 | 97.8 | 93.5 | 89.9 | 88.6 | 93.5 |
| SARSr-Rp-BatCoV ZXC21/R.pusillus/Zhejiang/2015 | 88.3 | 99.0 | 95.6 | 98.8 | 94.7 | 88.2 | 98.0 | 95.4 |
| SARSr-Rp-BatCoV ZC45/R.pusillus/Zhejiang/2017 | 92.8 | 99.0 | 95.9 | 99.3 | 94.5 | 89.0 | 98.0 | 95.8 |
| Pangolin-SARSr-CoV Guangxi/P4L/2017 | 85.5 | 97.1 | 97.9 | 98.2 | 97.0 | 94.5 | 97.7 | 96.9 |
| SARSr-Ra-BatCoV RaTG13/R.affinis/Yunnan/2013 | 96.7 | 99.3 | 99.6 | 99.7 | 99.2 | 97.7 | 100 | 99.2 |
*ADRP, ADP-ribose-1′′ phosphatase; nsp, nonstuctural protein; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; SARSr-CoV, severe acute respiratory syndrome–related coronavirus.
1These authors contributed equally to this article.
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