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Volume 26, Number 7—July 2020
Dispatch

Clinical Management of Argentine Hemorrhagic Fever using Ribavirin and Favipiravir, Belgium, 2020

Ioannis Veliziotis, Alain Roman, Delphine Martiny, Gerlind Schuldt, Marc Claus, Nicolas DaubyComments to Author , Sigi Van den Wijngaert, Charlotte Martin, Rakan Nasreddine, Claudia Perandones, Romain Mahieu, Corien Swaan, Serge Van Praet, Deborah Konopnicki, Maria A. Morales, Denis Malvy, Etienne Stevens, Philippe Dechamps, Erika Vlieghe, Olivier Vandenberg, Stephan Günther1, and Michèle Gérard1
Author affiliations: Université de Bruxelles, Brussels, Belgium (I. Veliziotis, A. Roman, D. Martiny, M. Claus, N. Dauby, S. Van den Wijngaert, C. Martin, R. Nasreddine, D. Konopnicki, E. Stevens, P. Dechamps, O. Vandenberg, M. Gérard); Saint-Pierre University Hospital, Brussels (I. Veliziotis, A, Roman, M. Claus, N. Dauby, C. Martin, R. Nasreddine, S. Van Praet, D. Konopnicki, E. Stevens, P. Deschamps, M. Gérard); Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. (G. Schuldt, S. Günther); National Administration of Laboratories and Institutes of Health, Buenos Aires, Argentina (C. Perandones); Common Community Commission, Brussels (R. Mahieu); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (C. Swaan); Instituto Nacional de Enfermedades Virales Humanas, Pergamino, Argentina (M.A. Morales); World Health Organization Collaborating Centre for Reference and Research of Arbovirus and Hemorrhagic Fever Virosis, Pergamino (M.A. Morales); University Hospital Center of Bordeaux, Bordeaux, France (D. Malvy); University Hospital Antwerp, Belgium (E. Vlieghe); University College London, London, UK (O. Vandenberg)

Main Article

Figure

Biologic and virologic evolution in relation to treatment and supportive care for a patient with Argentine hemorrhagic fever, Belgium, 2020. A) Evolution of maximum daily temperature and blood and urine viral load during hospitalization. Antiviral and antimicrobial drug treatment scheme are shown. Dosages of FVP are indicated in grams. B) Evolution of hemoglobin, total leukocytes, and platelets during hospitalization. Solid arrows indicate administration of red blood cell units, and dashed arrow

Figure. Biologic and virologic evolution in relation to treatment and supportive care for a patient with Argentine hemorrhagic fever, Belgium, 2020. A) Evolution of maximum daily temperature and blood and urine viral load during hospitalization. Antiviral and antimicrobial drug treatment scheme are shown. Dosages of FVP are indicated in grams. B) Evolution of hemoglobin, total leukocytes, and platelets during hospitalization. Solid arrows indicate administration of red blood cell units, and dashed arrows indicate administration of G-CSF. Ct values <40 indicate undetectable viral load. CRO, ceftriaxone; Ct, cycle threshold; CXM, cefuroxime; FVP, favipiravir; G-CSF, granulocyte colony-stimulating factor; MEM, meropenem; Neg., negative; RBV, ribavirin; TZP, piperacillin/tazobactam; VRC, voriconazole; WBC, white blood cells.

Main Article

1These senior authors contributed equally to this article.

Page created: April 09, 2020
Page updated: June 18, 2020
Page reviewed: June 18, 2020
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