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Volume 26, Number 7—July 2020
Dispatch

Clinical Management of Argentine Hemorrhagic Fever using Ribavirin and Favipiravir, Belgium, 2020

Ioannis Veliziotis, Alain Roman, Delphine Martiny, Gerlind Schuldt, Marc Claus, Nicolas DaubyComments to Author , Sigi Van den Wijngaert, Charlotte Martin, Rakan Nasreddine, Claudia Perandones, Romain Mahieu, Corien Swaan, Serge Van Praet, Deborah Konopnicki, Maria A. Morales, Denis Malvy, Etienne Stevens, Philippe Dechamps, Erika Vlieghe, Olivier Vandenberg, Stephan Günther1, and Michèle Gérard1
Author affiliations: Université de Bruxelles, Brussels, Belgium (I. Veliziotis, A. Roman, D. Martiny, M. Claus, N. Dauby, S. Van den Wijngaert, C. Martin, R. Nasreddine, D. Konopnicki, E. Stevens, P. Dechamps, O. Vandenberg, M. Gérard); Saint-Pierre University Hospital, Brussels (I. Veliziotis, A, Roman, M. Claus, N. Dauby, C. Martin, R. Nasreddine, S. Van Praet, D. Konopnicki, E. Stevens, P. Deschamps, M. Gérard); Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. (G. Schuldt, S. Günther); National Administration of Laboratories and Institutes of Health, Buenos Aires, Argentina (C. Perandones); Common Community Commission, Brussels (R. Mahieu); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (C. Swaan); Instituto Nacional de Enfermedades Virales Humanas, Pergamino, Argentina (M.A. Morales); World Health Organization Collaborating Centre for Reference and Research of Arbovirus and Hemorrhagic Fever Virosis, Pergamino (M.A. Morales); University Hospital Center of Bordeaux, Bordeaux, France (D. Malvy); University Hospital Antwerp, Belgium (E. Vlieghe); University College London, London, UK (O. Vandenberg)

Main Article

Table 1

Laboratory findings for a patient with Argentine hemorrhagic fever, Belgium, 2020*

Parameter Reference ranges/values Day 1 (ED) Day 2 (ICU) Day 9 Day 21 Day 43
Hemoglobin, g/dL 12.0–16.0 15.1 12.3 6.1 7.2 9.3
Erythrocytes, x 106/μL 3.80–5.00 5.2 4.3 2.12 2.6 3.2
Hematocrit, % 35.0–47.0 43.1 35.2 NA 22.8 30.8
Platelets, x 103/μL 150–440 66 48 76 268 350
Leukocytes, x 103/μL 3.50–11.00 1.48 0,81 4 0.9 5.8
Neutrophils, % 40.0–75.0 72.5 61,7 80.5 NA 40.4
Lymphocytes, % 2.0–10.0 12.4 NA 11 NA 41.9
CRP, mg/L <5.0 3.1 2,4 60.9 137 5
Schistocytes/1,000 RBC <10 3 4 NA NA NA
Haptoglobin, mg/dL 30–200 NA <10 NA NA NA
Serum iron, μg/dL 50–170 NA 163 NA NA NA
Serum ferritin, μg/L 30–200 NA 36,209 NA NA NA
aPTT, s 18.7–32.1 38.8 38,3 NA NA NA
INR, s 0.95–1.31 1.19 1.34 NA NA NA
Fibrinogen, mg/dL 150–400 138 100 NA NA NA
d-dimer, ng/mL 0–500 NA >4,500 NA NA NA
AST, U/L <32 1416 1,502 518 72 NA
ALT, U/L <33 238 245 94 48 NA
ALP, U/L 35–104 165 187 NA NA NA
γ-GT, U/L 6–42 115 193 NA NA NA
LDH, U/L 135–214 NA 2,359 NA NA NA
Total bilirubin, mg/dL <1.2 NA 0,6 3.9 2.4 1.1
Creatinine kinase, U/L 26–192 NA 7,341 2,363 15 28
Triglycerides, mg/dL <150 NA 135 NA NA NA
C3, g/L 0.80–1.64 NA 0.3 NA NA NA
C4, g/L 0.10–0.40 NA 0.24 NA NA NA
HIV NA NA Negative NA NA NA
Yellow fever IgG/IgM NA NA Negative NA NA NA
Dengue virus IgG/IgM NA NA Negative NA NA NA
Leptospira sp. NA NA Negative NA NA NA
Chikungunya IgG/IgM NA NA Negative NA NA NA
Hantavirus IgG/IgM NA NA Negative NA NA NA
Malaria NA Negative Negative NA NA NA

*ALP, alkaline phosphatase; ALT, alanine aminotransferase; aPTT, activated partial thromboplastin time; AST, aspartate aminotransferase;
CRP, C-reactive protein; ED, emergency department; γ-GT, γ-glutamyltransferase; ICU, intensive care unit; INR, international normalized ratio; LDH, lactate dehydrogenase; NA, not available; RBC, red blood cells.

Main Article

1These senior authors contributed equally to this article.

Page created: April 09, 2020
Page updated: June 18, 2020
Page reviewed: June 18, 2020
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