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Volume 26, Number 8—August 2020
Research

Population Genomic Structure and Recent Evolution of Plasmodium knowlesi, Peninsular Malaysia

Suzanne E. Hocking, Paul C.S. Divis, Khamisah A. Kadir, Balbir Singh, and David J. ConwayComments to Author 
Author affiliations: London School of Hygiene and Tropical Medicine Department of Infection Biology, London, UK (S.E. Hocking, D.J. Conway); Universiti Sarawak Malaysia Malaria Research Centre, Kota Samarahan, Malaysia (P.C.S. Divis, K.A. Kadir, B. Singh, D.J. Conway)

Main Article

Figure 6

Summary of nucleotide site allele frequency distributions by Tajima’s D indices for all 4,742 Plasmodium knowlesi genes with >3 SNPs among the 28 cluster 3 P. knowlesi infections in Peninsular Malaysia. A) Overall values were negatively skewed with a mean Tajima’s D of −0.86, consistent with a pattern that would be caused by long-term population size expansion. B) Data for all individual genes show that those with high Tajima’s D values are distributed throughout the genome. Some of these gen

Figure 6. Summary of nucleotide site allele frequency distributions by Tajima’s D indices for all 4,742 Plasmodium knowlesi genes with >3 SNPs among the 28 cluster 3 P. knowlesi infections in Peninsular Malaysia. A) Overall values were negatively skewed with a mean Tajima’s D of −0.86, consistent with a pattern that would be caused by long-term population size expansion. B) Data for all individual genes show that those with high Tajima’s D values are distributed throughout the genome. Some of these genes are likely to be underbalancing selection (individual values for all genes are shown in Appendix 2 Datasheet 2).

Main Article

Page created: May 18, 2020
Page updated: June 25, 2020
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