Volume 26, Number 8—August 2020
Increased Sensitivity of Plasmodium falciparum to Artesunate/Amodiaquine Despite 14 Years as First-Line Malaria Treatment, Zanzibar
|Year of study, group||No patients*||No. (%) positive on day 3||No. (%) with parasite recrudescence†||No. (%) with recurrent new infection||p value‡|
|2002–2003, all patients§||206||1 (0.5)||13 (6)||44 (22)||Referent|
|2005, all patients§||172||0||7 (4)||16 (9)||Referent|
|2017, all patients||142||1 (1)||0||0||0.003|
|2017, children <5 y of age||21||0||0||0||0.614|
|2017, children <10 y of age||42||0||0||0||0.243|
|2017, children <15 y of age||66||0||0||0||0.055|
|2017, >2,000 parasites/µL||115||0||0||0||0.006|
*Number fulfilling follow-up as per protocol.
†After PCR correction.
‡p value when compared with 2002–2003 and 2005 combined.
§All patients were ≤5 y of age and had parasite densities >2,000 parasites/µL in 2002–2003 and 2005.
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Page updated: July 17, 2020
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