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Volume 26, Number 8—August 2020
Research

Increased Sensitivity of Plasmodium falciparum to Artesunate/Amodiaquine Despite 14 Years as First-Line Malaria Treatment, Zanzibar

Mwinyi Msellem, Ulrika Morris, Aungpaing Soe, Faiza B. Abbas, Abdul-Wahid Ali, Rory Barnes, Paolo Frumento, Abdullah S. Ali, Andreas Mårtensson, and Anders BjörkmanComments to Author 
Author affiliations: Mnazi Mmoja Hospital, Zanzibar, Tanzania (M. Msellem); Karolinska Institutet, Stockholm, Sweden (U. Morris, A. Soe, R. Barnes, P. Frumento, A. Bjorkman); Zanzibar Malaria Elimination Programme, Zanzibar, Tanzania (F.B. Abbas, A.-W. Ali, A.S. Ali); Uppsala University, Uppsala, Sweden (A. Mårtensson)

Main Article

Table 6

Association between PCR positivity on days 3, 7, and 28 after treatment and patient characteristics at study baseline, Zanzibar*

Characteristic PCR negative, day 3 PCR positive, day 3 p value,† day 3 PCR negative, day 7 PCR positive, day 7 p value,† day 7 PCR negative, day 28 PCR positive, day 28 p value,† day 28
Total (%)
52/142 (37)
90/142 (63)
NA
100/142 (70)
42/142 (30)
NA
133/142 (94)
9/142 (6)

M:F ratio
33:19
65:25
0.35
70:30
28:14
0.70
91:42
72
0.72
Median age, y (range)
24 (2–57)
14 (2–60)
<0.001
19 (2–60)
12.5 (2–54)
0.01
17 (2–60)
14 (9–56)
0.54
Geometric mean parasite density/µL (range)
3,998 
(75–120,955)
12,011 
(78–304,269)
<0.001
6,185 
(76–145,750)
14,940 (561–304,269)
0.01
7,847
(78–304,269)
11,259 (2,730–56,304)
0.61
Mean ± SD temperature, °C
37.2 ± 1.2
38.1 ± 1.3
<0.001
37.7 ± 1.4
38.0 ± 1.2
0.27
37.8 ± 1.4
38.0 ± 1.2
0.62
Mean ± SD hemoglobin level, g/dL 12.4 ± 2.2 11.7 ± 2.2 0.09 12.2 ± 2.2 11.3 ± 2.2 0.01 12.0 ± 2.3 11.4 ± 1.5 0.37

*NA, not applicable.
†Calculated by Fisher exact test (for sex) or Wilcoxon rank-sum (Mann-Whitney) test for continuous variables.

Main Article

Page created: May 26, 2020
Page updated: July 17, 2020
Page reviewed: July 17, 2020
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