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Volume 26, Number 8—August 2020
Dispatch

Leishmania donovani Infection with Atypical Cutaneous Manifestations, Himachal Pradesh, India, 2014–2018

Lovlesh Thakur, Kiran K. Singh, Hemant R. Kushwaha, Sudarshan K. Sharma, Vinay Shankar, Ajeet Negi, Ghanshyam Verma, Sandhya Kumari, Aklank Jain, and Manju JainComments to Author 
Author affiliations: Central University of Punjab, Bathinda, India (L. Thakur, K.K. Singh, A. Jain, M. Jain); Jawaharlal Nehru University, New Delhi, India (H.R. Kushwaha); Indira Gandhi Medical College, Shimla, India (S.K. Sharma, A. Negi, G. Verma, S. Kumari); Maharishi Markandeshwar Medical College and Hospital, Kumarhatti-Solan, India (V. Shankar)

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Figure 2

6PGDH-based molecular analysis of clinical isolates from cutaneous leishmaniasis (CL) patients, Himachal Pradesh, India, 2014–2018. A) Sequence alignment of partial 6PGDH amino acid of CL isolates exhibit replacement of asparagine (N) with aspartic acid (D) at position 326 analogous to visceral leishmaniasis–causing and CL-causing isolates from Sri Lanka. B) Phylogenetic tree for 6PGDH sequences from CL test isolates (designated as HPCL, numbered in order of their collection) and standard Leishm

Figure 2. 6PGDH-based molecular analysis of clinical isolates from cutaneous leishmaniasis (CL) patients, Himachal Pradesh, India, 2014–2018. A) Sequence alignment of partial 6PGDH amino acid of CL isolates exhibit replacement of asparagine (N) with aspartic acid (D) at position 326 analogous to visceral leishmaniasis–causing and CL-causing isolates from Sri Lanka. B) Phylogenetic tree for 6PGDH sequences from CL test isolates (designated as HPCL, numbered in order of their collection) and standard Leishmania strains. Tree constructed by using maximum-likelihood method with 5,000 bootstraps in the dnaml program of PHYLIP package (http://evolution.genetics.washington.edu/phylip/doc/main.html). GenBank accession numbers are indicated. Scale bar indicates the amino acid substitution per site. 6PGDH, 6-phosphogluconate dehydrogenase gene; HP, Himachal Pradesh.

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Page created: June 10, 2020
Page updated: July 18, 2020
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