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Volume 26, Number 8—August 2020
Dispatch

Evolution and Antigenic Drift of Influenza A (H7N9) Viruses, China, 2017–2019

Jiahao Zhang1, Hejia Ye1, Huanan Li1, Kaixiong Ma, Weihong Qiu, Yiqun Chen, Ziwen Qiu, Bo Li, Weixin Jia, Zhaoping Liang, Ming LiaoComments to Author , and Wenbao QiComments to Author 
Author affiliations: College of Veterinary Medicine, South China Agricultural University, Guangzhou, China (J. Zhang, H. Li, K. Ma, Y. Chen, Z. Qiu, B. Li, W. Jia, M. Liao, W. Qi); National Avian Influenza Para-Reference Laboratory, Ministry of Agriculture and Rural Affairs of the People’s Republic of China, Guangzhou (J. Zhang, H. Li, W. Jia, M. Liao, W. Qi); Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs of the People’s Republic of China, Guangzhou (J. Zhang, W. Jia, M. Liao, W. Qi); National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, National Development and Reform Commission, Guangzhou (J. Zhang, W. Jia, M. Liao, W. Qi); Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Guangzhou (J. Zhang, W. Jia, M. Liao, W. Qi); Guangzhou South China Biological Medicine Co., Ltd, Guangzhou (H. Ye, W. Qiu, Z. Liang); Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou (W. Jia, M. Liao, W. Qi)

Main Article

Table 1

Results of hemagglutinin inhibition assay in study of evolution and antigenic drift of influenza A(H7N9) viruses, China, 2019*

Antigen Antiserum, titer
H7N9-Re-2† H7N9-rGD76† 181115 H7SD12 H71903‡ LN19010 19225 19294
H7N9-Re-2 1,024 2,048 256 512 512 1,024 1,024 2,048
H7N9-rGD76 128 1,024 128 512 256 256 256 128
181115 64 256 1,024 256 256 256 128 128
H7SD12 64 256 256 1,024 1,024 2048 1,024 1,024
H71903 64 512 256 1,024 1,024 1,024 2048 1,024
LN19010 32 256 32 512 512 512 512 512
19225 32 256 64 1,024 512 1,024 512 1,024
19294 32 256 64 512 512 1,024 512 512
19300–1 32 256 64 1,024 512 1,024 512 512
19743 16 64 16 512 256 256 256 128
19797 16 32 16 256 128 128 64 128
19854–2 16 64 16 512 256 256 256 256
19854–6 16 64 16 256 256 512 256 256
LN191012 16 64 16 512 256 256 128 128
AH191005 32 128 32 1,024 512 256 256 256

*181115, A/chicken/northeast China/181115/2018(H7N9); H7SD12, A/chicken/east China/H7SD12/2019(H7N9); HeB1908, A/chicken/north China/HeB1908/2019(H7N9); LN19010, A/chicken/northeast China/LN19010/2019(H7N9); 19225, A/chicken/northeast China/19225/2019(H7N9); 19294, A/chicken/northeast China/19294/2019(H7N9); 19300–1, A/chicken/northeast China/19300–1/2019(H7N9); 19743, A/chicken/northeast China/19743/2019(H7N9); 19797, A/chicken/northeast China/197971/2019(H7N9); 19854–2, A/chicken/northeast China/19854–2/2019(H7N9); 19854–6, A/chicken/northeast China/19854–6/2019(H7N9); LN19010, A/chicken/northeast China/LN19010/2019(H7N9); LN191012, A/chicken/northeast China/LN191012/2019(H7N9); AH191005, A/chicken/east China/AH191005/2019(H7N9).
†H7N9-Re-2 and H7N9-rGD76 are vaccine strains widely used in China; both antigen and antiserum of H7N9-Re-2 were purchased from the Harbin Weike Biotechnology Development Company (www.hvriwk.com), the antigen of H7N9-Re-2 was available from reassortant avian influenza virus trivalent vaccine. The antigen and antiserum of H7N9-rGD76 were available from Guangzhou South China Biologic Medicine (http://www.gzscbm.com).
‡H71903 is candidate vaccine strain containing the hemagglutinin and neuraminidase genes from H7SD12 and 6 internal genes from A/duck/Guangdong/D7/2007(H5N2). H7SD12, 181115, HeB1908, LN19010, 19225, 19294, 19300–1, 19743, 19797, 19854–2, 19854–6, LN19010, LN191012, and AH191005 are highly pathogenic H7N9 strains in this study.

Main Article

1These authors contributed equally to this article.

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