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Volume 26, Number 8—August 2020
Research Letter

Asymptomatic SARS-CoV-2 Infection in Household Contacts of a Healthcare Provider, Wuhan, China

Yi Luo1, Edwin Trevathan1, Zhengmin Qian, Yirong Li, Jin Li, Wei Xiao, Ning Tu, Zhikun Zeng, Pingzheng Mo, Yong Xiong, and Guangming YeComments to Author 
Author affiliations: Zhongnan Hospital, Wuhan University, Wuhan, China (Y. Luo, Y. Li, J. Li, Z. Zeng, P. Mo, Y. Xiong, G. Ye); Vanderbilt Institute for Global Health, Vanderbilt University Medical Center, Nashville, Tennessee, USA (E. Trevathan); Saint Louis University, St. Louis, Missouri, USA (Z. Qian); Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan (W. Xiao); Wuhan University Remin Hospital, Wuhan (N. Tu).

Main Article


Summary of laboratory results of a SARS-CoV-2–positive patient and 5 asymptomatic household contacts, Wuhan, China*

Laboratory test Reference range Patient 1 Contact 1 Contact 2† Contact 3‡ Contact 4 Contact 5
C-reactive protein, mg/L 0–10 18.8 2.0 0.4 0.4 1.5 2.7
Leukocyte count, × 109 cells/L 3.5–9.5 6.68 6.89 4.79 6.86 3.54 5.84
Lymphocyte ratio, % 20–50 17.70 18.50 45.50 67.90 34.60 33.10
CD19+ absolute count/μL 240–1317 140 147 626 767 271 299
ALT, U/L 7–45 45 11 520 16 15 7
AST, U/L 13–35 21 14 439 24 18 14
d-dimer, ng/mL 0–500 161 89 101 >3500 150 97

*ALT, alanine aminotransferase; AST, aspartate aminotransferase; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
†Contact 2 had 4 serial negative throat swabs for SARS-CoV-2, and negative influenza A, influenza B, respiratory syncytial virus, parainfluenza virus, adenoviridae, Epistein-Barr virus, cucumber mosaic virus, mycoplasma, and chlamydia results. He had elevated AST and ALT and was negative for hepatitis A, B, C, and E; he had no jaundice or gastrointestinal symptoms. His AST and ALT returned to normal after 9 days of treatment with glycyrrhizinate 50 mg 3 times daily and vitamin C (0.2 g 3×/d).
‡Contact 3 had an elevated D-dimer level without anemia, bleeding, or evidence of a coagulopathy. She received vitamin C (0.2 g 3 ×/d). After the SARS-CoV-2 nucleic acid (throat swab) test was negative, her D-dimer level returned to normal (111 ng/mL).

Main Article

1These first authors contributed equally to this article.

Page created: April 24, 2020
Page updated: July 19, 2020
Page reviewed: July 19, 2020
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