TY - JOUR AU - Zhou, Ling-Hong AU - Jiang, Ying-Kui AU - Li, Ruo-Yu AU - Huang, Li-Ping AU - Yip, Ching-Wan AU - Denning, David AU - Zhu, Li-Ping T1 - Risk-Based Estimate of Human Fungal Disease Burden, China T2 - Emerging Infectious Disease journal PY - 2020 VL - 26 IS - 9 SP - 2137 SN - 1080-6059 AB - We conducted a systematic literature review to obtain risk population–based fungal disease incidence or prevalence data from China. Data were categorized by risk factors and extrapolated by using most recent demographic figures. A total of 71,316,101 cases (5.0% of the population) were attributed to 12 risk factors and 17 fungal diseases. Excluding recurrent Candida vaginitis (4,057/100,000 women) and onychomycosis (2,600/100,000 persons), aspergillosis (317/100,000 persons) was the most common problem; prevalence exceeded that in most other countries. Cryptococcal meningitis, an opportunistic infection, occurs in immunocompetent persons almost twice as often as AIDS. The pattern of fungal infections also varies geographically; Talaromyces marneffei is distributed mainly in the Pearl River Basin, and the Yangtze River bears the greatest histoplasmosis burden. New host populations, new endemic patterns, and high fungal burdens in China, which caused a huge impact on public health, underscore the urgent need for building diagnostic and therapeutic capacity. KW - fungal disease KW - burden KW - China KW - fungi KW - prevalence KW - risk factor DO - 10.3201/eid2609.200016 UR - https://wwwnc.cdc.gov/eid/article/26/9/20-0016_article ER - End of Reference