TY - JOUR AU - Menu, Estelle AU - Criscuolo, Alexis AU - Desnos-Ollivier, Marie AU - Cassagne, Carole AU - D’Incan, Evelyne AU - Furst, Sabine AU - Ranque, Stéphane AU - Berger, Pierre AU - Dromer, Françoise T1 - Saprochaete clavata Outbreak Infecting Cancer Center through Dishwasher T2 - Emerging Infectious Disease journal PY - 2020 VL - 26 IS - 9 SP - 2031 SN - 1080-6059 AB - Saprochaete clavata is a pathogenic yeast responsible for rare outbreaks involving immunocompromised patients, especially those with hematologic malignancies. During February 2016–December 2017, we diagnosed S. clavata infections in 9 patients (8 with fungemia), including 3 within 1 month, at a cancer center in Marseille, France. The patients (median age 58 years), 4 of 9 of whom had acute myeloid leukemia, were hospitalized in 3 different wards. Ten environmental samples, including from 2 dishwashers and 4 pitchers, grew S. clavata, but no contaminated food was discovered. The outbreak ended after contaminated utensils and appliances were discarded. Whole-genome sequencing analysis demonstrated that all clinical and environmental isolates belonged to the same phylogenetic clade, which was unrelated to clades from previous S. clavata outbreaks in France. We identified a dishwasher with a deficient heating system as the vector of contamination. KW - acute myeloid leukemia KW - France KW - fungemia KW - fungi KW - genome sequencing KW - hematological malignancies KW - pathogenic yeasts KW - phylogenetic clades KW - Saprochaete clavata DO - 10.3201/eid2609.200341 UR - https://wwwnc.cdc.gov/eid/article/26/9/20-0341_article ER - End of Reference