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Volume 27, Number 1—January 2021
Research

Differential Yellow Fever Susceptibility in New World Nonhuman Primates, Comparison with Humans, and Implications for Surveillance

Natália C.C. de Azevedo FernandesComments to Author , Juliana M. Guerra, Josué Díaz-Delgado, Mariana S. Cunha, Leila delC. Saad, Silvia D. Iglezias, Rodrigo A. Ressio, Cinthya dos Santos Cirqueira, Cristina T. Kanamura, Isis P. Jesus, Adriana Y. Maeda, Fernanda G.S. Vasami, Júlia de Carvalho, Leonardo J.T. de Araújo, Renato Pereira de Souza, Juliana S. Nogueira, Roberta M.F. Spinola, and José L. Catão-Dias
Author affiliations: Instituto Adolfo Lutz, São Paulo, Brazil (N.C.C. de Azevedo Fernandes, J.M. Guerra, J. Díaz-Delgado, M.S. Cunha, S.D. Iglezias, R.A. Ressio, C. dos Santos Cirqueira, C.T. Kanamura, I.P. Jesus, A.Y. Maeda, F.G.S. Vasami, J. de Carvalho, L.T. de Araújo, R. Pereira de Souza, J.S. Nogueira); Universidade de São Paulo, São Paulo (N.C.C. de Azevedo Fernandes, J.M. Guerra, J. Díaz-Delgado, J.L. Catão-Dias); Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, Texas, USA (J. Díaz-Delgado); Centro de Vigilância Epidemiológica Prof. Alexandre Vranjac, São Paulo (L.D.C. Saad, R.M.F. Spinola)

Main Article

Table 2

Summary of main findings of human and NWP cases of yellow fever, Brazil*

Category Human NWP genus
Alouatta spp., n = 445 Sapajus spp., n = 13 Callithrix spp., n = 25 Callicebus spp., n = 9
Sex
M 40 208 5 9 3
F
 8
 79
 5
 5
 5
Age
Humans, y
0–19 0
20–30 5
31–45 13
46–65 24
>65 7
NWP, category
Cub 18 0 1 0
Young 39 4 0 3
Adult
165
 5
 11
 4
Hepatic histology†
Full spectrum of YF-associated lesions 45 403 12 9 8
Incomplete spectrum of YF-associated lesions 3 11 0 15 1
IHC and RT-qPCR profile
Concordant 46 223 5 7 4
Discordant
 2
 7
 0
 14
 1
Quantification cycle
<10 0 73 2 3 3
11–20 28 147 3 4 1
21–30 17 5 0 0 0
>30 3 5 0 14 1

*IHC, immunohistochemical analysis; NA, not applicable; NWPs, New Word primates; RT-qPCR, reverse transcription quantitative PCR.
†Cases with marked autolysis were excluded.

Main Article

Page created: October 05, 2020
Page updated: December 21, 2020
Page reviewed: December 21, 2020
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