Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 27, Number 1—January 2021

Differential Yellow Fever Susceptibility in New World Nonhuman Primates, Comparison with Humans, and Implications for Surveillance

Natália C.C. de Azevedo FernandesComments to Author , Juliana M. Guerra, Josué Díaz-Delgado, Mariana S. Cunha, Leila delC. Saad, Silvia D. Iglezias, Rodrigo A. Ressio, Cinthya dos Santos Cirqueira, Cristina T. Kanamura, Isis P. Jesus, Adriana Y. Maeda, Fernanda G.S. Vasami, Júlia de Carvalho, Leonardo J.T. de Araújo, Renato Pereira de Souza, Juliana S. Nogueira, Roberta M.F. Spinola, and José L. Catão-Dias
Author affiliations: Instituto Adolfo Lutz, São Paulo, Brazil (N.C.C. de Azevedo Fernandes, J.M. Guerra, J. Díaz-Delgado, M.S. Cunha, S.D. Iglezias, R.A. Ressio, C. dos Santos Cirqueira, C.T. Kanamura, I.P. Jesus, A.Y. Maeda, F.G.S. Vasami, J. de Carvalho, L.T. de Araújo, R. Pereira de Souza, J.S. Nogueira); Universidade de São Paulo, São Paulo (N.C.C. de Azevedo Fernandes, J.M. Guerra, J. Díaz-Delgado, J.L. Catão-Dias); Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, Texas, USA (J. Díaz-Delgado); Centro de Vigilância Epidemiológica Prof. Alexandre Vranjac, São Paulo (L.D.C. Saad, R.M.F. Spinola)

Main Article

Table 3

Performance of histopathologic analysis in diagnosing yellow fever in NWPs and humans, Brazil*

Category Sensitivity Specificity PPV NPV IHC and qRT-PCR agreement, κ
All genera 94.1 (91.6–96.1) 99.5 (98.8–99.8) 98.6 (97–99.4) 97.6 (96.6–98.3) 0.97 (0.91–0.96)
Alouatta 97.3 (95.3–98.7) 98.2 (95.6–99.5) 99 (97–99.4) 95.3 (91.9–97.3) 0.95 (0.92–0.98)
Callithrix 37.5 (18.8–59.4) 99.9 (99.3–100.0) 90.0 (54.3–98.6) 98.2 (97.5–98.7) 0.47 (0.25–0.70)
Sapajus 100 (73.5–100.0) 100 (94.4–100.0) 100 (94.4–100.0) 100.0 (94.4–100.0) 0.90 (0.70–1.00)
88.9 (51.7–99.7)
94.7 (74.0–99.9)
88.9 (53.9–98.2)
94.7 (73.9–99.1)
0.85 (0.56–1.00)
Humans 97.9 (88.7–99.9) 97.8 (88.5–99.9) 97.9 (86.9–99.7) 97.8 (86.6–99.7) 0.96 (0.90–1.00)

*Values are % (95% CI). IHC, immunohistochemical analysis; NPV, negative predictive value; NWPs, New Word primates; PPV, positive predictive value; RT-qPCR, reverse transcription quantitative PCR.

Main Article

Page created: October 05, 2020
Page updated: December 21, 2020
Page reviewed: December 21, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.