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Volume 27, Number 1—January 2021
Research

IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Henry M. Staines1, Daniela E. Kirwan1, David J. Clark1, Emily R. Adams, Yolanda Augustin, Rachel L. Byrne, Michael Cocozza, Ana I. Cubas-Atienzar, Luis E. Cuevas, Martina Cusinato, Benedict M.O. Davies, Mark Davis, Paul Davis, Annelyse Duvoix, Nicholas M. Eckersley, Daniel Forton, Alice J. Fraser, Gala Garrod, Linda Hadcocks, Qinxue Hu, Michael Johnson, Grant A. Kay, Kesja Klekotko, Zawditu Lewis, Derek C. Macallan, Josephine Mensah-Kane, Stefanie Menzies, Irene Monahan, Catherine M. Moore, Gerhard Nebe-von-Caron, Sophie I. Owen, Chris Sainter, Amadou A. Sall, James Schouten, Christopher T. Williams, John Wilkins, Kevin Woolston, Joseph R.A. Fitchett, Sanjeev Krishna2Comments to Author , and Tim Planche2Comments to Author 
Author affiliations: St. George’s, University of London, London, UK (H.M. Staines, D.E. Kirwan, D.J. Clark, Y. Augustin, M. Cuisinato, B.M.O. Davies, N.M. Eckersley, D. Forton, L. Hadcocks, Q. Hu, D.C. Macallan, I. Monahan, C.M. Moore, S. Krishna, T. Planche); Liverpool School of Tropical Medicine, Liverpool, UK (E.R. Adams, R.L. Byrne, A.I. Cubas-Atienzar, L.E. Cuevas, A.J. Fraser, G. Garrod, G.A. Kay, S. Menzies, S.I. Owen, C.T. Williams); Mologic, Thurleigh, UK (M. Cocozza, M. Davis, P. Davis, A. Duvoix, M. Johnson, K. Klekotko, Z. Lewis, J. Mensah-Kane, G. Nebe-von-Caron, C. Sainter, J. Schouten, J. Wilkins, K. Woolston, J.R.A. Fitchett); St. George’s University Hospitals National Health Services Foundation Trust, London (D. Forton, S. Krishna, T. Planche); Institut Pasteur, Dakar, Senegal (A.A. Sall); Universitätsklinikum Tübingen, Tübingen, Germany (S. Krishna); Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon (S. Krishna)

Main Article

Table 2

Selected laboratory values of patients with severe acute respiratory syndrome coronavirus 2 infection, United Kingdom, 2020*

Variable (reference range) At diagnosis
 Peak
No. Median (IQR) No. Median (IQR)
C-reactive protein (0–5 mg/L) 134 86 (52.5–164) 176 215.5 (103–334)
Nadir lymphocytes count (1.1–4.0 × 109/L) 134 0.9 (0.6–1.4) 177 0.6 (0.4–0.8)
Ferritin (30–400 μg/L) 42 1,084 (630–1,721) 89 1,335 (846–2,758)
Fibrinogen (1.6–4.8 g/L) 133 5.5 (4.2–6.7) 166 7.0 (5.5–9.15)
D-dimer (21–300 ng/mL) 64 704 (395–1,079) 111 1,905 (498–4,095)
Lactate dehydrogenase (0–250 U/L) 47 475 (280–597.5) 87 490 (344.5–704)

*IQR, interquartile range.

Main Article

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: October 17, 2020
Page updated: December 21, 2020
Page reviewed: December 21, 2020
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