Volume 27, Number 11—November 2021
Research
Changing Patterns of Disease Severity in Blastomyces dermatitidis Infection, Quebec, Canada
Alex Carignan
, Chiheb Boudhrioua, Sandrine Moreira, Andrée Ann Pelletier, Kevin Dufour, Jacques Pépin, Catherine Allard, Dominique Marcoux, and Philippe J. Dufresne
, Chiheb Boudhrioua, Sandrine Moreira, Andrée Ann Pelletier, Kevin Dufour, Jacques Pépin, Catherine Allard, Dominique Marcoux, and Philippe J. Dufresne
Table 1
Characteristics of patients in study of blastomycosis in Quebec, Canada*
| Characteristic | 1988–1997, n = 33 | 1998–2007, n = 57 | 2008–2017, n = 95 | p value |
|---|---|---|---|---|
| Median age, y (IQR) |
47.4 (42.9–61.2) |
50.0 (40.4–62.8) |
58.9 (48.6–70.6) |
0.02† |
| Sex | ||||
| F | 11 (33) | 13 (23) | 18 (19) | |
| M |
22 (67) |
44 (77) |
77 (81) |
0.2 |
| No. involved organs | ||||
| 1 | 17 (52) | 34 (60) | 70 (74) | |
| >2 |
16 (48) |
23 (40) |
25 (26) |
0.04 |
| Underlying conditions | ||||
| Chronic obstructive pulmonary disease | 6 (18) | 7 (12) | 21 (22) | 0.3 |
| Diabetes | 1 (3) | 9 (16) | 22 (23) | 0.03 |
| Immunosuppression |
2 (6) |
11 (19) |
31 (33) |
0.005 |
| Charlson Comorbidity Index | ||||
| 0 | 20 (61) | 28 (49) | 33 (35) | |
| 1–2 | 11 (33) | 12 (21) | 30 (32) | |
| >3 |
2 (6) |
17 (30) |
32 (34) |
0.01 |
| First antifungal administered | ||||
| Amphotericin B, lipid formulations | 0 | 5 (9) | 20 (21) | |
| Amphotericin B, deoxycholate | 5 (15) | 6 (11) | 6 (6) | |
| Azole | 20 (61) | 33 (58) | 58 (61) | |
| No treatment |
8 (24) |
13 (23) |
11 (12) |
0.008‡ |
| Blastomyces genotype group | ||||
| I | 1 (6) | 1 (2) | 1 (2) | |
| II | 3 (17) | 11 (24) | 11 (24) | |
| III | 4 (22) | 13 (29) | 14 (30) | |
| IV |
10 (56) |
20 (44) |
20 (44) |
0.9 |
| Severe illness |
1 (3) |
8 (15) |
21 (22) |
0.03 |
| 90-day all-cause mortality | 2 (6) | 10 (18) | 18 (19) | 0.2 |
*Values are no. (%) except as indicated. IQR, interquartile range. †By Mood's equality of medians test. ‡By Fisher exact test.
Page created: September 11, 2021
Page updated: October 19, 2021
Page reviewed: October 19, 2021
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