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Volume 27, Number 11—November 2021
Research

Genomic Profiling of Mycobacterium tuberculosis Strains, Myanmar

Htin Lin Aung1Comments to Author , Wint Wint Nyunt1, Yang Fong, Patrick J. Biggs, Richard C. Winkworth, Peter J. Lockhart, Tsin Wen Yeo, Philip C. Hill, Gregory M. Cook, and Si Thu Aung
Author affiliations: University of Otago, Dunedin, New Zealand (H.L. Aung, P.C. Hill, G.M. Cook); Ministry of Health and Sports, Yangon, Myanmar (W.W. Nyunt); Massey University, Palmerston North, New Zealand (Y. Fong, P.J. Biggs, R.C. Winkworth, P.J. Lockhart); Nanyang Technological University, Singapore (T.W. Yeo); Ministry of Health and Sports, Naypyitaw, Myanmar (S.T. Aung)

Main Article

Table 2

Comparison of phenotypic drug susceptibility testing and genomic resistance mutation results for Mycobacterium tuberculosis strains, Myanmar*

Drug Performance of genome-based† drug resistance profile prediction with respect to phenotypic drug-susceptibility testing
Mutation
 No mutation
 Sensitivity, % Specificity, %
Sensitive Resistant Sensitive Resistant
Isonizaid 0 196 113 0 100.0 100.0
Rifampin 0 191 118 0 100.0 100.0
Ethambutol 34 80 155 40 70.2 79.5
Streptomycin 26 140 80 63 84.3 55.9
Ofloxacin/levofloxacin/capreomycin 13 31 263 2 70.4 99.2
Amikacin/kanamycin 0 6 303 0 100.0 100.0
Para-aminosalicylic acid 15 0 294 0 NA 100.0
Ethionamide 4 28 274 3 87.5 98.9
D-cycloserine 0 0 309 0 NA 100.0

*NA, not applicable. †Whole-genome sequencing‒based prediction.

Main Article

1These authors contributed equally to this article.

Page created: July 13, 2021
Page updated: October 19, 2021
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