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Volume 27, Number 11—November 2021
Dispatch

Correlation of SARS-CoV-2 Subgenomic RNA with Antigen Detection in Nasal Midturbinate Swab Specimens

Katherine Immergluck1, Mark D. Gonzalez, Jennifer K. Frediani, Joshua M. Levy, Janet Figueroa, Anna Wood, Beverly B. Rogers, Jared O’Neal, Roger Elias-Marcellin, Allie Suessmith, Julie Sullivan, Raymond F. Schinazi, Ahmed Babiker, Anne Piantadosi, Miriam B. Vos, Greg S. Martin, Wilbur A. Lam, and Jesse J. WaggonerComments to Author 
Author affiliations: Emory University, Atlanta, Georgia, USA (K. Immergluck, M.D. Gonzalez, J.K. Frediani, J.M. Levy, J. Figueroa, A. Wood, B.B. Rogers, J. O’Neal, R. Elias-Marcellin, A. Suessmith, J. Sullivan, R.F. Schinazi, A. Babiker, A. Piantadosi, M.B. Vos, G.S. Martin, W.A. Lam, J.J. Waggoner); The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta (K. Immergluck, M.D. Gonzalez, J.K. Frediani, J.M. Levy, J. Figueroa, A. Wood, B.B. Rogers, J. O’Neal, A. Suessmith, J. Sullivan, R.F. Schinazi, M.B. Vos, G.S. Martin, W.A. Lam, J.J. Waggoner); Children’s Healthcare of Atlanta, Atlanta (M.D. Gonzalez, M.B. Vos)

Main Article

Figure 1

Correlation of sgRNA levels with total SARS-CoV-2 RNA in samples from study participants in Atlanta, Georgia, USA. A) N2 Ct values for samples in which sgRNA was detectable (gray dots) or not detectable (red dots). Horizontal bars indicate means, and error bars indicate SDs. B) sgRNA Ct values versus corresponding Ct values for the N2 target. Results of simple linear regression (black line) and error bars (dotted lines) are shown. Line of identity (gray line) is shown for reference. Ct, cycle threshold; N2, nucleocapsid 2; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; sgRNA, subgenomic RNA.

Figure 1. Correlation of sgRNA levels with total SARS-CoV-2 RNA in samples from study participants in Atlanta, Georgia, USA. A) N2 Ct values for samples in which sgRNA was detectable (gray dots) or not detectable (red dots). Horizontal bars indicate means, and error bars indicate SDs. B) sgRNA Ct values versus corresponding Ct values for the N2 target. Results of simple linear regression (black line) and error bars (dotted lines) are shown. Line of identity (gray line) is shown for reference. Ct, cycle threshold; N2, nucleocapsid 2; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; sgRNA, subgenomic RNA.

Main Article

1Current affiliation: Pomona College, Claremont, California, USA.

Page created: August 18, 2021
Page updated: October 19, 2021
Page reviewed: October 19, 2021
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