TY - JOUR AU - Hogan, Catherine AU - Jassem, Agatha AU - Sbihi, Hind AU - Joffres, Yayuk AU - Tyson, John AU - Noftall, Kyle AU - Taylor, Marsha AU - Lee, Tracy AU - Fjell, Chris AU - Wilmer, Amanda AU - Galbraith, John AU - Romney, Marc AU - Henry, Bonnie AU - Krajden, Mel AU - Galanis, Eleni AU - Prystajecky, Natalie AU - Hoang, Linda M.N. T1 - Rapid Increase in SARS-CoV-2 P.1 Lineage Leading to Codominance with B.1.1.7 Lineage, British Columbia, Canada, January–April 2021 T2 - Emerging Infectious Disease journal PY - 2021 VL - 27 IS - 11 SP - 2802 SN - 1080-6059 AB - Several severe acute respiratory syndrome coronavirus 2 variants of concern (VOCs) emerged in late 2020; lineage B.1.1.7 initially dominated globally. However, lineages B.1.351 and P.1 represent potentially greater risk for transmission and immune escape. In British Columbia, Canada, B.1.1.7 and B.1.351 were first identified in December 2020 and P.1 in February 2021. We combined quantitative PCR and whole-genome sequencing to assess relative contribution of VOCs in nearly 67,000 infections during the first 16 weeks of 2021 in British Columbia. B.1.1.7 accounted for <10% of screened or sequenced specimens early on, increasing to >50% by week 8. P.1 accounted for <10% until week 10, increased rapidly to peak at week 12, and by week 13 codominated within 10% of rates of B.1.1.7. B.1.351 was a minority throughout. This rapid expansion of P.1 but suppression of B.1.351 expands our understanding of population-level VOC patterns and might provide clues to fitness determinants for emerging VOCs. KW - variant of concern KW - testing KW - public health KW - COVID-19 KW - coronavirus disease KW - SARS-CoV-2 KW - severe acute respiratory syndrome coronavirus 2 KW - viruses KW - respiratory infections KW - zoonoses KW - British Columbia KW - Canada KW - Suggested citation for this article: Hogan CA KW - Jassem AN KW - Sbihi H KW - Joffres Y KW - Tyson JR KW - Noftall K KW - et al. Rapid increase in SARS-CoV-2 P.1 lineage leading to codominance with B.1.1.7 lineage KW - January–April 2021. Emerg Infect Dis. 2021 Nov [date cited]. https://doi.org/10.3201/eid2711.211190 DO - 10.3201/eid2711.211190 UR - https://wwwnc.cdc.gov/eid/article/27/11/21-1190_article ER - End of Reference