TY - JOUR AU - Cassmann, Eric AU - Moore, S. AU - Greenlee, Justin T1 - Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep T2 - Emerging Infectious Disease journal PY - 2021 VL - 27 IS - 12 SP - 3156 SN - 1080-6059 AB - Chronic wasting disease (CWD) is a fatal prion disease of cervids. We examined host range of CWD by oronasally inoculating Suffolk sheep with brain homogenate from a CWD-positive white-tailed deer. Sixty months after inoculation, 1/7 sheep had immunoreactivity against the misfolded form of prion protein in lymphoid tissue. Results were confirmed by mouse bioassay. KW - chronic wasting disease KW - CWD KW - chronic wasting disease agent KW - prions and related diseases KW - transmissible spongiform encephalopathies KW - animal diseases KW - experimental oronasal transmission KW - white-tailed deer KW - Suffolk sheep KW - zoonoses DO - 10.3201/eid2712.204978 UR - https://wwwnc.cdc.gov/eid/article/27/12/20-4978_article ER - End of Reference