Volume 27, Number 2—February 2021
Dispatch
Shuni Virus in Cases of Neurologic Disease in Humans, South Africa
Table 1
Demographic and clinical information of SHUV-positive CSF samples from 7 patients hospitalized with neurologic signs, Gauteng Province, South Africa, 2017*
| Sample ID | Patient age/sex | Other symptoms | Clinical diagnoses | HIV status | Other tests | Vaccination | Reason for discharge | Location |
|---|---|---|---|---|---|---|---|---|
| ZRUNH039/17 |
29 y/F |
Not stated |
Meningitis |
Unknown |
Not stated |
Unknown |
Unknown |
JHB |
| ZRUNH131/17 |
1 y 9 mo/M |
Not stated |
TB, meningitis |
Unknown |
Not stated |
Unknown |
Unknown |
JHB |
| ZRUNH219/17 |
6 mo/F |
Vomiting, diarrhea, fine maculopapular rash |
Acute gastroenteritis and shock |
Mother (positive), on HAART/
PMTCT, ART (FDC); baby received nevirapine |
H. influenzae Ag (negative), N. meningitidis ACV W135 (negative), E. coli (negative), S. pneumonia (negative), GBS (negative), cryptococcal Ag (negative) |
Mother did not have clinic card |
Stable |
Eastlynne, Pretoria |
| ZRUNH212/17 |
2 y 8 mo/M |
Coughing blood, otitis media, simple febrile seizures, fever (38°C), difficulty breathing, vomiting, diarrhea; had second episode of seizure |
Upper respiratory tract infection/ hemoptysis/ febrile convulsions |
Mother negative; baby received nevirapine |
Not stated |
Up to date: BGG, polio+DPT (3–18 mo), DT (5 y) not done |
Stable |
Pretoria |
| ZRUNH208/17 |
4 y 11 mo/M |
Seizures, ICU patient, decreased LOC, vomiting, seizures, fever, diarrhea |
Encephalitis and aspiration pneumonia |
Negative |
Microbiology: negative for bacteria |
Incomplete: no polio+DPT (4,5 mo) |
Not stated |
Eastlynne, Pretoria |
| ZRUNH213/17 |
13 d/F |
ICU patient, baby delivered normally, neonatal encephalopathy, second-degree congenital sepsis/TORCH, poor sucking, premature, low birthweight, nonimmune, subcutaneous edema, abdominal distension (HC, chest, AC), abdominal U/S (ascites, bilateral dense kidneys) |
Nonimmune hydrops fetalis |
Not stated |
HSV (positive; patient tested negative following treatment), rubella PCR (IgG positive, IgM negative), CMV (IgG positive, IgM negative) |
Up to date |
Stable |
Mamelodi East, Pretoria |
| ZRUNH400/17 | 4 mo/M | Respiratory distress, vomiting bile | Viral pneumonia | Not stated | Not stated | Up to date | Not stated | Olieven-houtbosch, Pretoria |
*AC, abdominal circumference; Ag, antigen; BCG, bacille Calmette-Guérin; CMV, cytomegalovirus; DPT, diphtheria/pertussis/tetanus; E. coli, Escherichia coli; FDC, fixed-dose combination; GBS, group B Streptococcus; H. influenzae, Haemophilus influenzae; HAART, highly active antiretroviral therapy; HC, hepatitis C; HSV, herpes simplex virus; ICU, intensive care unit; ID, identification; JHB, Johannesburg; LOC, level of consciousness; N. meningitis, Neisseria meningitidis; PMTCT, prevention of mother-to-child transmission; SHUV, Shuni virus; TB, tuberculosis; TORCH, Toxoplasma gondii; U/S, ultrasound.