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Volume 27, Number 2—February 2021
Research

Role of Burkholderia pseudomallei–Specific IgG2 in Adults with Acute Melioidosis, Thailand

Panjaporn Chaichana, Kemajittra Jenjaroen, Suchintana Chumseng, Manutsanun Sumonwiriya, Patpong Rongkard, Barbara Kronsteiner, Prapit Teparrukkul, Direk Limmathurotsakul, Nicholas P.J. Day, Narisara Chantratita, and Susanna J DunachieComments to Author 
Author affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand (P. Chaichana, K. Jenjaroen, S. Chumseng, M. Sumonwiriya, P. Rongkard, D. Limmathurotsakul, N.P.J. Day, N. Chantratita, S.J. Dunachie); University of Oxford, Oxford, England (P. Rongkard, B. Kronsteiner, D. Limmathurotsakul, N.P.J. Day, S. Dunachie); Sunpasithiprasong Hospital, Ubon Ratchathani, Thailand (P. Teparrukkul)

Main Article

Figure 1

Comparison of serum levels of Burkholderia pseudomallei–specific antibody subclasses between 94 survivors and 45 nonsurvivors of acute melioidosis, Thailand. A) IgM; B) total IgG; C) IgG1; D) IgG2; E) IgG3; and F) IgG4. Serum levels were tested by using indirect ELISA on heat-killed whole cell B. pseudomallei. We used Kruskal-Wallis 1-way ANOVA to compare >2 groups and Mann-Whitney U to compare 2 groups. Antibody levels in healthy endemic controls (n = 30) are shown for comparison for total IgM and IgG only. OD450, optical density at 450 nm.

Figure 1. Comparison of serum levels of Burkholderia pseudomallei–specific antibody subclasses between 94 survivors and 45 nonsurvivors of acute melioidosis, Thailand. A) IgM; B) total IgG; C) IgG1; D) IgG2; E) IgG3; and F) IgG4. Serum levels were tested by using indirect ELISA on heat-killed whole cell B. pseudomallei. We used Kruskal-Wallis 1-way ANOVA to compare >2 groups and Mann-Whitney U to compare 2 groups. Antibody levels in healthy endemic controls (n = 30) are shown for comparison for total IgM and IgG only. OD450, optical density at 450 nm.

Main Article

Page created: December 14, 2020
Page updated: January 23, 2021
Page reviewed: January 23, 2021
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