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Volume 27, Number 2—February 2021
Dispatch

SARS-CoV-2 Infections among Recent Organ Recipients, March–May 2020, United States

Jefferson M. JonesComments to Author , Ian Kracalik, Meenakshi M. Rana, Ann Nguyen, Brian C. Keller, Aaron Mishkin, Charles Hoopes, Thomas Kaleekal, Abhinav Humar, Juan Vilaro, Gene Im, Lou Smith, April Justice, Collette Leaumont, Stephen Lindstrom, Brett Whitaker, Ricardo M. La Hoz, Marian G. Michaels, David Klassen, Wendi Kuhnert, and Sridhar V. Basavaraju
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (J.M. Jones, I. Kracalik, C. Leaumont, S. Lindstrom, B. Whitaker, W. Kuhnert, S.V. Basavaraju); Icahn School of Medicine at Mount Sinai, New York, New York, USA (M.M. Rana, G. Im); University of Chicago, Chicago, Illinois, USA (A. Nguyen); The Ohio State University College of Medicine, Columbus, Ohio, USA (B.C. Keller); Temple University, Philadelphia, Pennsylvania, USA (A. Mishkin); University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA (C. Hoopes); Robert Wood Johnson University, New Brunswick, New Jersey, USA (T. Kaleekal); University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (A. Humar, M.G. Michaels); University of Florida College of Medicine, Gainesville, Florida, USA (J. Vilaro); New York State Department of Health, Albany, New York, USA (L. Smith); Ohio Department of Health, Columbus (A. Justice); University of Texas Southwestern Medical Center, Dallas, Texas, USA (R.M. La Hoz); United Network of Organ Sharing, Richmond, Virginia, USA (D. Klassen)

Main Article

Table 2

Epidemiologic and clinical characteristics of index recipients associated with SARS-CoV-2 transmission in recipients of solid-organ transplants, United States, March–May 2020*

Index recipient Donor Organ Symptoms No. days from transplant to symptom onset Exposure to persons with COVID-19 No. days in hospital† No. days in ICU‡ No. days intubated‡ COVID-19 treatment Immunosuppressive medications, induction Immunosuppressive medications, maintenance Patient status
A
A
Bilateral lungs
Fever, respiratory failure, diaphoresis, atrial fibrillation, shock, acute kidney failure
6
Confirmed COVID-19 among HCW contacts, potential nosocomial transmission
109
35
41
Hydroxychloroquine, azithromycin
Basiliximab, methylprednisolone
Mycophenolate, tacrolimus, prednisone
Alive
B
B
Single lung
Fever, nasal congestion
14
Confirmed COVID-19 among HCW contacts
31
None
None
Hydroxychloroquine
Basiliximab, methylprednisolone
Mycophenolate, tacrolimus, prednisone
Alive
C
C
Liver
Altered mental status, fever, respiratory failure
9
Confirmed COVID-19 among household contacts
79
66
64
Convalescent plasma
Basiliximab
Everolimus, prednisone
Dead
D
D
Liver
Cough
7
Suspected nosocomial transmission at transplant center
49
19
19
Hydroxychloroquine, azithromycin
Methylprednisolone
Tacrolimus, mycophenolate mofetil, prednisone
Dead
E
E
Bilateral lungs
None
Asymptomatic
Confirmed COVID-19 among HCW contacts
17
4
2
Chloroquine
Basiliximab, methylprednisolone, mycophenolate mofetil
Tacrolimus, mycophenolate mofetil, prednisone
Alive
F
F
Single lung
Fever, dyspnea, wheezing
7
Suspected nosocomial transmission at transplant center
14
14
9
Remdesivir, azithromycin, intravenous immunoglobulin
Basiliximab
Tacrolimus, mycophenolate mofetil, prednisone
Dead
G
G
Heart and single kidney
Tachycardia, respiratory failure
81
Confirmed COVID-19 among household contacts
10
9
7
Hydroxychloroquine, azithromycin
Basiliximab, methylprednisolone
Tacrolimus, mycophenolate mofetil, prednisone
Alive
H H Heart Dyspnea, fever, diarrhea 9 Suspected nosocomial transmission at transplant center 84 77 9 Remdesivir, azithromycin, tocilizumab Basiliximab, methylprednisolone, mycophenolate mofetil Tacrolimus, mycophenolate mofetil, methylprednisolone Alive

*For all recipients, SARS-COV-2 test was by nasopharyngeal swab. COVID-19, coronavirus disease; HCW, healthcare worker; ICU, intensive care unit; SARS-COV-2, severe acute respiratory syndrome coronavirus 2.
†If patient never discharged since organ transplantation, number of days hospitalized since organ transplantation. If patient discharged and re-admitted, number of days hospitalized since most recent admission.
‡For patients C, D, and F, day of death is considered last day of hospitalization, day in ICU, or day intubated.

Main Article

Page created: December 10, 2020
Page updated: January 24, 2021
Page reviewed: January 24, 2021
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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