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Volume 27, Number 3—March 2021
Research Letter

COVID-19–Associated Fusobacterium nucleatum Bacteremia, Belgium

Louis Wolff, Delphine Martiny, Véronique Yvette Miendje Deyi, Evelyne Maillart, Philippe Clevenbergh, and Nicolas DaubyComments to Author 
Author affiliations: Université Libre de Bruxelles, Brussels, Belgium (L. Wolff, D. Martiny, V.Y. Miendje Deyi, E. Maillart, P. Clevenbergh, N. Dauby); Saint-Pierre University Hospital Brussels, Brussels (L. Wolff, N. Dauby); Université de Mons, Mons, Belgium (D. Martiny); Laboratoire Hospitalier Universitaire de Bruxelles–Universitair Laboratorium Brussel, Brussels, (D. Martiny, V.Y. Miendje Deyi); Brugmann University Hospital, Brussels (E. Maillart, P. Clevenbergh)

Main Article

Table

Characteristics of 4 cases of Fusobacterium nucleatum bacteremia in patients with COVID-19, Belgium*

Characteristic Patient 1 Patient 2 Patient 3 Patient 4
Age, y
52
51
34
70
COVID-19 diagnosis
Day of admission
Day of admission
Day of admission
Day of admission
Symptoms at diagnosis
Dry cough and sore throat for 7 d
Cough, abdominal pain, and diarrhea for 7 d
Cough, abdominal pain, and diarrhea for 7 d
Fever (38.5°C),
vomiting for 1 d
Underlying conditions
Hypertension
Diabetes, hypertension, obesity
None
Diabetes, hypertension, hypothyroidism, history of stroke
Radiological findings
Chest CT Ground glass opacities in all lobes Diffuse infiltrates in all lobes Ground glass opacities in 10% of lungs Ground glass opacities in 10% of lungs
Abdominal CT with contrast
NA
NA
Unremarkable
Unremarkable
Blood culture collection Day 1 Day 15 Day 1 Day 1
Time to positivity (no. sets)
96 h (1 of 2)
55 h (1 of 2)
72 h (1 of 2)
72 h (1 of 2)
COVID-19 therapy
HCQ 400 mg oral 2×/d on day 1, then 200 mg 2×/d for 4 d
HCQ 400 mg oral 2×/d on day 1, then 200 mg 2×/d for 4 d; TCZ 800 mg IV once; and RDV 200 mg IV loading dose, then 100 mg 4×/d for 4 d
None
None
Antimicrobial drug therapy
None
TZP 4 g IV 4×/d for 6 d
MTZ 500 mg orally 3×/d for 7 d
None
F. nucleatum antimicrobial susceptibility testing
Amoxicillin/clavulanic S S S S
Clindamycine S S S S
Imipenem S S S S
Metronidazole S S S S
Piperacilline/tazobactam
S
S
S
S
Outcome Discharged home Died Discharged home Discharged home

*COVID-19, coronavirus disease; CT, computed tomography; HCQ, hydroxychloroquine; IV, intravenous; MTZ, metronidazole; RDV, remdesivir; S, susceptible; TCZ, tocilizumab; TZP, piperacilline-tazobactam.

Main Article

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CrossMark reports this article was originally posted as a Preprint at https://doi.org/10.1101/2020.02.17.20023721. (Ref. 4 "Xiao, Tang, Zheng, Liu, Li, Shan, 2020")

CrossMark reports this article was originally posted as a Preprint at https://doi.org/10.1101/2020.04.25.060350. (Ref. 7 "Lamers, Beumer, van der Vaart, Knoops, Puschhof, Breugem, et al., 2020")

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Page updated: February 22, 2021
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