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Volume 27, Number 3—March 2021
CME ACTIVITY - Research

Fluconazole-Resistant Candida glabrata Bloodstream Isolates, South Korea, 2008–2018

Eun Jeong Won1, Min Ji Choi1, Mi-Na Kim, Dongeun Yong, Wee Gyo Lee, Young Uh, Taek Soo Kim, Seung Ah Byeon, Seung Yeob Lee, Soo Hyun Kim, and Jong Hee ShinComments to Author 
Author affiliations: Chonnam National University Medical School, Gwangju, South Korea (E.J. Won, M.J. Choi, S.A. Byeon, S.Y. Lee, S.H. Kim, J.H. Shin); Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea (M.-N. Kim); Yonsei University College of Medicine, Seoul (D. Yong); Ajou University School of Medicine, Suwon, South Korea (W.G. Lee); Yonsei University Wonju College of Medicine, Wonju, South Korea (Y. Uh); Seoul National University College of Medicine, Seoul (T.S. Kim)

Main Article

Table 2

Pdr1 AAS in 66 FR isolates and 212 F-SDD BSI isolates of Candida glabrata and their MLST genotypes, based on cultures collected during a multicenter surveillance study, South Korea, 2008–2018*

MLST genotype Fluconazole susceptibility No. isolates tested No. with echinocandin resistance No. isolates with 5 Pdr1p AAS found in both FR and F-SDD isolates
 No. isolates with additional Pdr1p AAS except for 5 Pdr1p AAS
P76S P143T D243N E259G T745A 1 2 Total
ST7 FR 37 6† 34 3 37
F-SDD
 98
 3
0
0
ST3 FR 7 0 7 7 7 6 1 7
F-SDD
 43
 1
 43
 43
 43
0
0
ST26 FR 7 0 6 6
F-SDD
 10
 1
0
0
ST22 FR 1 0 1 1
F-SDD
 16
 1
0
0
ST10 FR 2 0 2 2
F-SDD
 9
 0
0
0
ST55 FR 2 0 2 2 2
F-SDD
 6
 1
6
1
1
ST2 FR 2 0 2 2
F-SDD
 3
 0
0
0
ST6 FR 1 0 1 1
F-SDD
 5
 2
0
0
ST59 FR 1 0 1 1 1
F-SDD
 3
 1
3
0
0
ST1
 FR
 2
 0
2
2
ST12
 F-SDD
 2
 0
0
0
Other STs‡
 FR 4 0 1 2 2 4
F-SDD
 17
 0
 2
 2
 2
1
1
Total, no. (%) FR 66 6 7 7 7 3 1 59 6§ 65 (98.5)
F-SDD 212 10 45 45 45 6 3 2¶ 2 (0.9)

*AAS, amino acid substitution; BSI, bloodstream infection; FR, fluconazole-resistant; F-SDD, fluconazole-susceptible dose-dependent; MLST, multilocus sequence typing; ST, sequence type.
†All 6 isolates showed multidrug resistance, defined as resistance to both fluconazole and echinocandins.
‡Includes 21 STs that were each unique to a single isolate.
§Each of 6 FR isolates harbored 2 additional Pdr1 AAS (E340G/D919Y [ST7], Y556C/F580I [ST7], N132S/G1099S [ST7], F832L/L833V [ST3], G189V/E340G [other ST], and L366P/E555D [other ST]).
¶Two F-SDD isolates harbored additional Pdr1 AAS (V502I [ST55] and R250K [other ST]).

Main Article

1These first authors contributed equally to this article.

Page created: January 04, 2021
Page updated: March 01, 2021
Page reviewed: March 01, 2021
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