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Volume 27, Number 3—March 2021
CME ACTIVITY - Research

Effectiveness of Preventive Therapy for Persons Exposed at Home to Drug-Resistant Tuberculosis, Karachi, Pakistan

Amyn A. MalikComments to Author , Neel R. Gandhi, Timothy L. Lash, Lisa M. Cranmer, Saad B. Omer, Junaid F. Ahmed, Sara Siddiqui, Farhana Amanullah, Aamir J. Khan, Salmaan Keshavjee, Hamidah Hussain1, and Mercedes C. Becerra1
Author affiliations: Emory University Rollins School of Public Health, Atlanta, Georgia, USA (A.A. Malik, N.R. Gandhi, T.L. Lash); Yale University, New Haven, Connecticut, USA (A.A. Malik, S.B. Omer); Global Health Directorate, Indus Health Network, Karachi, Pakistan (A.A. Malik, J.F. Ahmed, S. Siddiqui); Interactive Research and Development, Singapore (A.A. Malik, A.J. Khan, H. Hussain); Emory University School of Medicine, Atlanta (N.R. Gandhi, L.M. Cranmer); Emory + Children’s Pediatric Institute, Atlanta (L.M. Cranmer); The Indus Hospital, Karachi (F. Amanullah); Harvard University, Cambridge, Massachusetts, USA (A.J. Khan, S. Keshavjee, M.C. Becerra); Partners In Health, Boston, Massachusetts, USA (S. Keshavjee, M.C. Becerra); Brigham and Women’s Hospital, Boston (S. Keshavjee, M.C. Becerra)

Main Article

Table 1

Preventive therapy regimens in study of persons exposed at home to drug-resistant tuberculosis, Karachi, Pakistan, February 2016–March 2017*

Regimen Drug 1, dose Drug 2, dose
Levofloxacin/ethambutol
 Levofloxacin, <5 y: 15–20 mg/kg, >5 y: 7.5–10 mg/kg; max. dose 1,000 mg/d
 Ethambutol, 15–25 mg/kg; max. dose 2,000 mg/kg
Levofloxacin/ethionamide
 Levofloxacin, <5 y: 15–20 mg/kg, >5 y: 7.5–10 mg/kg; max. dose 1,000 mg/d
 Ethionamide, 15–20 mg/kg; max. dose 750 mg/kg
Moxifloxacin/ethambutol
 Moxifloxacin, 7.5–10 mg/kg; max. dose 400 mg/d
 Ethambutol, 15–25 mg/kg; max. dose 2,000 mg/kg
Moxifloxacin/ethionamide
 Moxifloxacin, 7.5–10 mg/kg; max. dose 400 mg/d
 Ethionamide, 15–20 mg/kg; max. dose 750 mg/kg
*Max., maximum.

Main Article

1These authors contributed equally to this article.

Page created: January 11, 2021
Page updated: February 19, 2021
Page reviewed: February 19, 2021
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